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Features of hereditary spastic paraplegias in North African region

      Hereditary spastic paraplegias (HSP) constitute a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by slowly progressive spasticity in the lower limbs. Different modes of inheritance have been described and the recent advances in molecular genetics techniques contribute to the identification of more than 75 different loci and about 60 corresponding genes responsible for HSP. Autosomal recessive forms HSP are often complicated associating additional features (ataxia, mental retardation, neuropathy…), however the autosomal dominant forms are usually pure.
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