Hereditary spastic paraplegias (HSP) constitute a clinically and genetically heterogeneous
group of neurodegenerative disorders characterized by slowly progressive spasticity
in the lower limbs. Different modes of inheritance have been described and the recent
advances in molecular genetics techniques contribute to the identification of more
than 75 different loci and about 60 corresponding genes responsible for HSP. Autosomal
recessive forms HSP are often complicated associating additional features (ataxia,
mental retardation, neuropathy…), however the autosomal dominant forms are usually
pure.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
