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Long-term inflammatory and neurodegenerative consequences of traumatic brain injury

  • D. Sharp
    Correspondence
    Corresponding author.
    Affiliations
    Imperial College London, The Computational- Cognitive and Clinical Neuroimaging Laboratory C3NL, London, United Kingdom
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      Traumatic brain injury (TBI) triggers progressive neurodegeneration, particularly affecting areas of traumatic axonal injury. Neuroinflammation characterized by persistent microglial activation is seen in degenerating white matter tracts many years after the initial injury. This provides a novel target for therapeutic intervention. However, a key question is whether microglial activation is damaging or reparative to neurons recovering from axonal injury?
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