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Plasticity of expert networks in health and disease

      Over the last two decades cognitive neuroscience brought new insights to several fields of high clinical relevance: neuropsychology, neuroimaging, neural plasticity, and neurorehabilitation. There is a general consensus that a better understanding of how the brain is organized, how its functioning is disrupted by lesions, and how we can promote its re-organization, is of prime importance to neurorehabilitation. As outlined in a recent review the link should be established between cognitive models and clinical trials (Clarke et al. 2015). Of particular interest are the effects of therapeutic interventions on cerebral re-organization. The brief interventions, such as prismatic adaptation for hemispatial neglect, are particularly suited for interventional imaging studies (Clarke and Bindschaedler 2014; Crottaz-Herbette et al. 2014; Clarke and Crottaz-Herbette 2016). Understanding better the mechanisms that underlie the effect of therapeutic interventions will help us to define more precisely the indications for specific treatments so that more focused randomized controlled trials can be performed.
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