- 1)What are the mechanisms of plasticity available to the CNS to mediate functional recovery?
- 2)Does the small size of most experimental animals influence the validity of findings for human therapeutic application?
- 3)In partial injury models, such as those commonly employed to study spinal cord injury, can we distinguish true regeneration of injured axons from collateral sprouting by spared axons, and why does it matter?
- 4)Are mechanisms of regeneration in the mature CNS the same as the mechanisms of axon outgrowth in embryonic development in vivo or in cell cultures?
- 5)What are the causes of regenerative failure in mammalian CNS axons? Since the known environmental inhibitory cues also are found in species whose axons regenerate, neuron-intrinsic differences must be important, such as the ability of injured axon tips to make their own protein.
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