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Letter to the Editor| Volume 379, P332, August 15, 2017

Vitamin D supplementation; effects on depressive symptoms in multiple sclerosis

      In a secondary analysis of data extracted from a larger trial, Rolf et al. reported that vitamin D (VitD; 14,000 IU daily for 9 months) had no significant effects either on depression ratings or on inflammatory biomarkers that might be associated with depression and multiple sclerosis (MS) [
      • Rolf L.
      • Muris A.-H.
      • Bol Y.
      • Damoiseaux J.
      • Smolders J.
      • Hupperts R.
      Vitamin D3 supplementation in multiple sclerosis: symptoms and biomarkers of depression.
      ]. We have scientific and ethical concerns about the study.
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      References

        • Rolf L.
        • Muris A.-H.
        • Bol Y.
        • Damoiseaux J.
        • Smolders J.
        • Hupperts R.
        Vitamin D3 supplementation in multiple sclerosis: symptoms and biomarkers of depression.
        J. Neurol. Sci. 2017; 378: 30-35
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        Addressing ethical lapses in research.
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        Multiple Scler. (Houndmills, Basingstoke, England). 2017; 23: 525-533