In a secondary analysis of data extracted from a larger trial, Rolf et al. reported that vitamin D (VitD; 14,000 IU daily for 9 months) had no significant effects either on depression ratings or on inflammatory biomarkers that might be associated with depression and multiple sclerosis (MS) [
]. We have scientific and ethical concerns about the study.
- Rolf L.
- Muris A.-H.
- Bol Y.
- Damoiseaux J.
- Smolders J.
- Hupperts R.
Vitamin D3 supplementation in multiple sclerosis: symptoms and biomarkers of depression.
J. Neurol. Sci. 2017; 378: 30-35
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- Vitamin D3 supplementation in multiple sclerosis: symptoms and biomarkers of depression.J. Neurol. Sci. 2017; 378: 30-35
- Addressing ethical lapses in research.JAMA Intern. Med. 2017; 177: 461-462
- A systematic review of modifiable risk factors in the progression of multiple sclerosis.Multiple Scler. (Houndmills, Basingstoke, England). 2017; 23: 525-533
Published online: June 09, 2017
Accepted: June 8, 2017
Received: May 17, 2017
© 2017 Elsevier B.V. All rights reserved.