Highlights
- •Long-term improvements in HRQOL were not maintained after STN-DBS in PD patients.
- •Improvement in motor functions was not correlated with HRQOL after STN-DBS.
- •Cognitive functions were relatively preserved after STN-DBS for five years.
Abstract
Introduction
We aimed to examine temporal changes in health-related quality of life (HRQOL) and
its relationship with motor and cognitive functions in patients with Parkinson's disease
(PD) after subthalamic nucleus deep brain stimulation (STN-DBS).
Methods
In total, 31 patients with PD were enrolled in this study (mean age: 66.7 ± 0.9 years; mean disease duration: 11.6 ± 3.7 years). Participants completed the Unified Parkinson's Disease Rating Scale and the
Parkinson's Disease Questionnaire-39. Cognitive function was assessed using the Mini
Mental State Examination, the Frontal Assessment Battery, and the Montreal Cognitive
Assessment. Postoperative evaluation was performed at three months, one year, three
years, and five years after surgery; temporal changes in the correlation between HRQOL
and motor and cognitive functions were evaluated at all follow-up periods.
Results
All patients completed postoperative clinical evaluations after three months, after
one year. Of the 31 participants, twelve completed postoperative clinical evaluations
after three years and seven after five years. Motor functions showed significant improvement
over the five-year follow-up period. The mobility subdomain of the HRQOL worsened
whereas the total score did not change significantly over years. Cognitive functions
were not significantly impaired during follow-up periods. HRQOL was basically not
significantly correlated with motor and cognitive functions during the follow-up period.
Conclusions
The mobility subdomain of the HRQOL worsened after surgery, and the improvement in
motor functions was basically not correlated with HRQOL after STN-DBS in patients
with PD. Cognitive functions were not significantly impaired during follow-up periods.
Keywords
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Article info
Publication history
Published online: May 19, 2017
Accepted:
May 18,
2017
Received in revised form:
May 12,
2017
Received:
November 13,
2016
Footnotes
☆Disclosure of conflict of interest: Authors declared no conflict of interest.
Identification
Copyright
© 2017 Published by Elsevier B.V.
