Highlights
- •The usefulness of SCP in diagnosis of PSP was assessed by a meta-analysis.
- •Age and HY stage contributed to SMD in size between PSP and PD.
- •PSP showed more reduced size of SCP than MSA with homogeneous studies.
- •There was no significant difference in ADC between groups including PSP, PD or MSA.
Abstract
Previous studies have reported the usefulness of superior cerebellar peduncle (SCP)
abnormalities in diagnosing progressive supranuclear palsy. However, the results of
these studies were heterogeneous. In the present meta-analysis, we aimed to establish
more robust evidence of SCP abnormalities in progressive supranuclear palsy, and to
determine the cause of the previously reported heterogeneity. We identified six studies
on SCP size and three studies on apparent diffusion coefficient. Key features of each
study were extracted and standardized differences in size and apparent diffusion coefficient
values were calculated. There was some heterogeneity in terms of the reduction in
SCP size in patients with progressive supranuclear palsy compared to those with Parkinson's
disease. Moreover, age and Hoehn-Yahr stage negatively correlated with standardized
mean difference in SCP size between patients with progressive supranuclear palsy and
Parkinson's disease. There was homogenous agreement that the SCP was smaller in patients
with progressive supranuclear palsy compared to those with multiple system atrophy.
Finally, in terms of apparent diffusion coefficient, there was no significant difference
between patients with progressive supranuclear palsy, Parkinson's disease, or multiple
system atrophy. Together, these findings suggest that SCP size, when corrected for
age and disease severity, could be a diagnostic tool for progressive supranuclear
palsy.
Keywords
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Article info
Publication history
Published online: May 02, 2017
Accepted:
May 2,
2017
Received in revised form:
April 19,
2017
Received:
December 14,
2016
Identification
Copyright
© 2017 Published by Elsevier B.V.
