Advertisement
Letter to the Editor| Volume 378, P137-139, July 15, 2017

Deep brain stimulation for Parkinson's disease: Subcutaneous apomorphine as an alternative for patients unable to tolerate surgery under local anesthesia

  • António Martins de Campos
    Correspondence
    Corresponding author at: Department of Neurology, Centro Hospitalar Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia, Portugal.
    Affiliations
    Department of Neurology, Centro Hospitalar Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia, Portugal
    Search for articles by this author
  • Luís Braz
    Affiliations
    Department of Neurology, Centro Hospitalar São João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal
    Search for articles by this author
  • Paulo Linhares
    Affiliations
    Department of Neurosurgery, Centro Hospitalar São João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal

    Movement Disorders and Functional Surgery Unit, Centro Hospitalar São João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal
    Search for articles by this author
  • Maria José Rosas
    Affiliations
    Department of Neurology, Centro Hospitalar São João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal

    Movement Disorders and Functional Surgery Unit, Centro Hospitalar São João, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal
    Search for articles by this author

      Highlights

      • Usually DBS surgery for PD is performed with the patient awake and deprived of medication.
      • We report a patient with severe dystonic features treated with apomorphine in the perioperative setting.
      • Apomorphine does not interfere with microelecrode recording or with the evaluation of the motor benefit of the stimulation.
      • Subcutaneous apomorphine can be an alternative for patients unable to tolerate surgery under local anesthesia.
      • This is, to the best of our knowledge, the first case report of apomorphine use with this purpose.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Lettieri C.
        • Rinaldo S.
        • Devigili G.
        • Pauletto G.
        • Verriello L.
        • Budai R.
        • et al.
        Deep brain stimulation: Subthalamic nucleus electrophysiological activity in awake and anesthetized patients.
        Clin. Neurophysiol. 2012; 123: 2406-2413
        • Slotty P.J.
        • Wille C.
        • Kinfe T.M.
        • Vesper J.
        Continuous perioperative apomorphine in deep brain stimulation surgery for Parkinson's disease.
        Br. J. Neurosurg. 2014; 28: 378-382
        • Harries A.M.
        • Kausar J.
        • Roberts S.A.G.
        • Mocroft A.P.
        • Hodson J.A.
        • Pall H.S.
        • Mitchell R.D.
        Deep brain stimulation of the subthalamic nucleus for advanced Parkinson disease using general anesthesia: long-term results.
        J. Neurosurg. 2012; 116: 107-113
        • Trenkwalder C.
        • Chaudhuri K.R.
        • Garcia Ruiz P.J.
        • LeWitt P.
        • Katzenschlager R.
        • Sixel-Doring F.
        • et al.
        Expert consensus group report on the use of apomorphine in the treatment of Parkinson's disease – clinical practice recommendations.
        Parkinsonism Relat. Disord. 2015; 21: 1023-1030