Research Article| Volume 378, P45-48, July 15, 2017

Effects of age and glucose levels on lactate levels in cerebrospinal fluid examination of neurodegenerative diseases

Published:April 20, 2017DOI:


      • Factors affecting CSF lactate levels in neurodegenerative were investigated.
      • CSF lactate levels and CSF glucose levels showed a moderate positive correlation.
      • Age and CSF glucose levels influenced CSF lactate levels even after adjustment by multiple regression analysis.
      • Age and CSF glucose levels should be taken into consideration upon the use of CSF lactate levels as a biomarker.


      Despite recent studies examining the association between neurodegenerative diseases and mitochondrial dysfunction, there are not sufficient data on factors that influence cerebrospinal fluid (CSF) lactate levels. Thus, we investigated factors that affect CSF lactate levels in neurodegenerative diseases. We extracted laboratory findings, including CSF lactate, glucose, and protein levels, and demographic and background information, including age and gender, from the electronic medical records of patients with neurodegenerative diseases in order to explore factors that have an impact CSF lactate levels. These patients had been admitted to our department and underwent a CSF examination between April 2007 and March 2015. Data from 83 patients (average age 64.5 years; 45 males and 38 females) were analyzed. The patients' diagnoses included amyotrophic lateral sclerosis, multiple system atrophy, spinocerebellar degeneration, corticobasal syndrome, Parkinson's disease, and Huntington's disease. CSF lactate levels were higher in patients with a neurodegenerative disease who were aged 65 years and older relative to those who were aged under 65 years (p < 0.05), and CSF lactate and glucose levels showed a moderate positive correlation (r = 0.487). Age and CSF glucose levels influenced CSF lactate levels even after adjusting for gender, age, CSF protein levels, and CSF glucose levels. When investigating CSF lactate levels in neurodegenerative diseases, it is necessary to consider patients' age and CSF glucose levels.


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