Highlights
- •Imaging of mGluR1 has the potential use for estimating cerebellar function.
- •Imaging of mGluR1 was compared with FDG imaging in the cerebellum.
- •Imaging of mGluR1 was comparable to FDG imaging in the cerebellum
- •Imaging of mGluR1 was more strongly associated with the degree of cerebellar ataxia.
- •Imaging of mGluR1 can be a more specific technique for evaluating cerebellar ataxia.
Abstract
Objective
Newly developed methods for imaging type 1 metabotropic glutamate receptor (mGluR1)
have the potential use for estimating cerebellar function. We aimed to compare mGluR1
imaging using N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-11C-methoxy-N-methylbenzamide (11C-ITMM) with the existing marker, fluorine-18-labeled fluorodeoxyglucose (18F-FDG) imaging, in the cerebellum.
Methods
Fourteen subjects consisting of 12 patients with cerebellar ataxia and two healthy
subjects underwent 11C-ITMM and 18F-FDG positron emission tomography. The degree of ataxia was scored with the Scale
for the Assessment and Rating of Ataxia (SARA). Volumes-of-interest were placed on
the anterior and posterior lobes and vermis. The binding potential (BPND) was calculated to estimate mGluR1 availability using the white matter as a reference
region. 18F-FDG uptake was normalized using the white matter (FUwm).
Results
There were significant positive correlations between the BPND and FUwm values in the anterior lobe (r = 0.83, P < 0.001), posterior lobe (r = 0.69, P = 0.009), and vermis (r = 0.58, P = 0.042). Regarding the relationship of SARA scores with the BPND and FUwm values, a significant negative correlation was found only in the anterior lobe between
the SARA scores and BPND values (r = −0.64, P = 0.029).
Conclusion
This study showed that mGluR1 imaging was comparable to 18F-FDG imaging in the cerebellum. However, mGluR1 imaging was more strongly associated
with the SARA scores than 18F-FDG imaging was, suggesting that mGluR1 imaging can be a more specific technique
than 18F-FDG imaging for evaluating cerebellar ataxia.
Keywords
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Article info
Publication history
Published online: January 13, 2017
Accepted:
January 10,
2017
Received in revised form:
January 10,
2017
Received:
November 9,
2016
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
