Highlights
- •Neuropsychiatric symptoms and behavioural disturbances are frequent in patients with Parkinson's disease.
- •Health related quality of life estimates the impact of a condition on the patient.
- •Neuropsychiatric disorders severely affect health-related quality of life.
- •The present review summarizes and updates current knowledge on the topic.
Abstract
Parkinson's disease is a complex neurodegenerative disorder characterized by motor
and non-motor symptoms, with neuropsychiatric manifestations among the most frequent
non-motor symptoms. Health-related quality of life is a patient-reported outcome that
reflects the impact of the disease on physical, mental, and social wellbeing, and
on other aspects of patient’ life. Although older studies on health-related quality
of life in Parkinson's disease mainly investigated the role of the motor impairment,
recent research focused on non-motor symptoms has highlighted the critical role that
behavioural disturbances due to neuropsychiatric symptoms play in determining health
related quality of life. A considerable number of studies have demonstrated the importance
of depression as a determinant of health-related quality of life in this population,
but less evidence is available regarding the role of other neuropsychiatric symptoms
such as anxiety, apathy, psychosis, and impulse control disorders. This narrative
review analyses recent literature on this topic, focusing on studies in which neuropsychiatric
symptoms were investigated as potential determinants of quality of life using regression
techniques, including discussion of the assessment tools used.
Keywords
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Article info
Publication history
Published online: January 13, 2017
Accepted:
December 27,
2016
Received:
December 14,
2016
Footnotes
☆This article is a reprint of a previously published article. For citation purposes, please use the original publication details; R. Balestrino, P. Martinez-Martin, Neuropsychiatric symptoms, behavioural disorders, and quality of life in Parkinson's disease, J. Neurol. Sci. 373 (2017) 173–178.
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© 2017 Elsevier B.V. All rights reserved.
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- Neuropsychiatric symptoms, behavioural disorders, and quality of life in Parkinson's diseaseJournal of the Neurological SciencesVol. 373
- PreviewParkinson's disease is a complex neurodegenerative disorder characterized by motor and non-motor symptoms, with neuropsychiatric manifestations among the most frequent non-motor symptoms. Health-related quality of life is a patient-reported outcome that reflects the impact of the disease on physical, mental, and social wellbeing, and on other aspects of patient’ life. Although older studies on health-related quality of life in Parkinson's disease mainly investigated the role of the motor impairment, recent research focused on non-motor symptoms has highlighted the critical role that behavioural disturbances due to neuropsychiatric symptoms play in determining health related quality of life.
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