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Phenomenology and epidemiology of impulsive-compulsive behaviours in Parkinson's disease, atypical Parkinsonian disorders and non-Parkinsonian populations

Published:December 28, 2016DOI:https://doi.org/10.1016/j.jns.2016.12.058

      Abstract

      Impulsive-compulsive behaviours are common, quality of life affecting consequences of dopamine replacement therapy which are well recognized in patients with idiopathic Parkinson's disease. Details of the occurrence and nature of these disorders in the atypical parkinsonian neurodegenerative disorders, and in non-Parkinson's patients prescribed dopaminergic stimulation for other disease processes, are slowly emerging. Here we review what is known about the phenomenology, epidemiology and risk factors for impulsive-compulsive behaviours in Parkinson's disease and in other, less well studied, patient groups. By analyzing the available published data, this review identifies potential clues as to the underlying neurobiological mechanism of these disorders, and further identifies critical gaps yet to be addressed.

      Keywords

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      References

        • Averbeck B.B.
        • O'Sullivan S.S.
        • Djamshidian A.
        Impulsive and compulsive behaviors in Parkinson's disease.
        Annu. Rev. Clin. Psychol. 2014; 10: 553-580
        • Schreiber L.
        • Odlaug B.L.
        • Grant J.E.
        Impulse control disorders: updated review of clinical characteristics and pharmacological management.
        Front. Psych. 2011; 2: 1
        • Weintraub D.
        • David A.S.
        • Evans A.H.
        • Grant J.E.
        • Stacy M.
        Clinical spectrum of impulse control disorders in Parkinson's disease.
        Mov. Disord. 2015; 30: 121-127
        • Association AP
        Diagnostic and Statistical Manual of Mental Disorders.
        fifth ed. American Psychiatric Publishing, Washington, DC2013
        • Grosset K.A.
        • Macphee G.
        • Pal G.
        • Stewart D.
        • Watt A.
        • Davie J.
        • et al.
        Problematic gambling on dopamine agonists: not such a rarity.
        Mov. Disord. 2006; 21: 2206-2208
        • Voon V.
        • Hassan K.
        • Zurowski M.
        • Duff-Canning S.
        • de Souza M.
        • Fox S.
        • et al.
        Prospective prevalence of pathologic gambling and medication association in Parkinson disease.
        Neurology. 2006; 66: 1750-1752
        • Weintraub D.
        • Koester J.
        • Potenza M.N.
        • Siderowf A.D.
        • Stacy M.
        • Voon V.
        • et al.
        Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients.
        Arch. Neurol. 2010; 67: 589-595
        • Gallagher D.A.
        • O'Sullivan S.S.
        • Evans A.H.
        • Lees A.J.
        • Schrag A.
        Pathological gambling in Parkinson's disease: risk factors and differences from dopamine dysregulation. An analysis of published case series.
        Mov. Disord. 2007; 22: 1757-1763
        • Djamshidian A.
        • Cardoso F.
        • Grosset D.
        • Bowden-Jones H.
        • Lees A.J.
        Pathological gambling in Parkinson's disease—a review of the literature.
        Mov. Disord. 2011; 26: 1976-1984
        • Voon V.
        • Hassan K.
        • Zurowski M.
        • de Souza M.
        • Thomsen T.
        • Fox S.
        • et al.
        Prevalence of repetitive and reward-seeking behaviors in Parkinson disease.
        Neurology. 2006; 67: 1254-1257
        • Raina G.
        • Cersosimo M.G.
        • Micheli F.
        Zoophilia and impulse control disorder in a patient with Parkinson disease.
        J. Neurol. 2012; 259: 969-970
        • Solla P.
        • Cannas A.
        • Marrosu M.G.
        • Marrosu F.
        Dopaminergic-induced paraphilias associated with impulse control and related disorders in patients with Parkinson disease.
        J. Neurol. 2012; 259: 2752-2754
        • O'Sullivan S.S.
        • Djamshidian A.
        • Evans A.H.
        • Loane C.M.
        • Lees A.J.
        • Lawrence A.D.
        Excessive hoarding in Parkinson's disease.
        Mov. Disord. 2010; 25: 1026-1033
        • McElroy S.L.
        • Keck Jr., P.E.
        • Pope Jr., H.G.
        • Smith J.M.
        • Strakowski S.M.
        Compulsive buying: a report of 20 cases.
        J. Clin. Psychiatry. 1994; 55: 242-248
        • Rylander G.
        Psychoses and the punding and choreiform syndromes in addiction to central stimulant drugs.
        Psychiatr. Neurol. Neurochir. 1972; 75: 203-212
        • Evans A.H.
        • Katzenschlager R.
        • Paviour D.
        • O'Sullivan J.D.
        • Appel S.
        • Lawrence A.D.
        • et al.
        Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome.
        Mov. Disord. 2004; 19: 397-405
        • Voon V.
        Repetition, repetition, and repetition: compulsive and punding behaviors in Parkinson's disease.
        Mov. Disord. 2004; 19: 367-370
        • O'Sullivan S.S.
        • Evans A.H.
        • Lees A.J.
        Punding in Parkinson's disease.
        Pract. Neurol. 2007; 7: 397-399
        • Miyasaki J.M.
        • Al Hassan K.
        • Lang A.E.
        • Voon V.
        Punding prevalence in Parkinson's disease.
        Mov. Disord. 2007; 22: 1179-1181
        • Giovannoni G.
        • O'Sullivan J.D.
        • Turner K.
        • Manson A.J.
        • Lees A.J.
        Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies.
        J. Neurol. Neurosurg. Psychiatry. 2000; 68: 423-428
        • Evans A.H.
        • Lawrence A.D.
        • Potts J.
        • Appel S.
        • Lees A.J.
        Factors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease.
        Neurology. 2005; 65: 1570-1574
        • Kim J.
        • Kim M.
        • Kwon D.Y.
        • Seo W.K.
        • Kim J.H.
        • Baik J.S.
        • Koh S.B.
        Clinical characteristics of impulse control and repetitive behavior disorders in Parkinson's disease.
        J. Neurol. 2013; 260: 429-437
        • [23]O'Sullivan S.S.
        • Evans A.H.
        • Quinn N.P.
        • Lawrence A.D.
        • Lees A.J.
        Reckless generosity in Parkinson's disease.
        Mov. Disord. 2010; 25: 221-223
        • Bienfait K.L.
        • Menza M.
        • Mark M.H.
        • Dobkin R.D.
        Impulsive smoking in a patient with Parkinson's disease treated with dopamine agonists.
        J. Clin. Neurosci. 2010; 17: 539-540
        • Friedman J.H.
        • Chang V.
        Crack cocaine use due to dopamine agonist therapy in Parkinson disease.
        Neurology. 2013; 80: 2269-2270
        • Avanzi M.
        • Baratti M.
        • Cabrini S.
        • Uber E.
        • Brighetti G.
        • Bonfa F.
        The thrill of reckless driving in patients with Parkinson's disease: an additional behavioural phenomenon in dopamine dysregulation syndrome?.
        Parkinsonism Relat. Disord. 2008; 14: 257-258
        • Micheli F.
        • Pellene A.
        • Arcushin D.
        • Calzinari A.
        • Farret M.S.
        Pet killing as a manifestation of impulse control disorder secondary to pramipexol.
        Clin. Neuropharmacol. 2015; 38: 55-56
        • Hoertel N.
        • Le Strat Y.
        • Schuster J.P.
        • Limosin F.
        Gender differences in firesetting: results from the national epidemiologic survey on alcohol and related conditions (NESARC).
        Psychiatry Res. 2011; 190: 352-358
        • Kessler R.C.
        • Coccaro E.F.
        • Fava M.
        • Jaeger S.
        • Jin R.
        • Walters E.
        The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication.
        Arch. Gen. Psychiatry. 2006; 63: 669-678
        • Evans A.H.
        • Pavese N.
        • Lawrence A.D.
        • Tai Y.F.
        • Appel S.
        • Doder M.
        • et al.
        Compulsive drug use linked to sensitized ventral striatal dopamine transmission.
        Ann. Neurol. 2006; 59: 852-858
        • Cilia R.
        • Siri C.
        • Marotta G.
        • Isaias I.U.
        • De Gaspari D.
        • Canesi M.
        • et al.
        Functional abnormalities underlying pathological gambling in Parkinson disease.
        Arch. Neurol. 2008; 65: 1604-1611
        • Djamshidian A.
        • Jha A.
        • O'Sullivan S.S.
        • Silveira-Moriyama L.
        • Jacobson C.
        • Brown P.
        • et al.
        Risk and learning in impulsive and nonimpulsive patients with Parkinson's disease.
        Mov. Disord. 2010; 25: 2203-2210
        • Kessler R.C.
        • Chiu W.T.
        • Demler O.
        • Merikangas K.R.
        • Walters E.E.
        Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.
        Arch. Gen. Psychiatry. 2005; 62: 617-627
        • Grant J.E.
        • Levine L.
        • Kim D.
        • Potenza M.N.
        Impulse control disorders in adult psychiatric inpatients.
        Am. J. Psychiatry. 2005; 162: 2184-2188
        • Hodgins D.C.
        • Stea J.N.
        • Grant J.E.
        Gambling disorders.
        Lancet. 2011; 378: 1874-1884
        • Welte J.
        • Barnes G.
        • Wieczorek W.
        • Tidwell M.C.
        • Parker J.
        Alcohol and gambling pathology among U.S. adults: prevalence, demographic patterns and comorbidity.
        J. Stud. Alcohol. 2001; 62: 706-712
        • Koran L.M.
        • Faber R.J.
        • Aboujaoude E.
        • Large M.D.
        • Serpe R.T.
        Estimated prevalence of compulsive buying behavior in the United States.
        Am. J. Psychiatry. 2006; 163: 1806-1812
        • Lee J.Y.
        • Kim J.M.
        • Kim J.W.
        • Cho J.
        • Lee W.Y.
        • Kim H.J.
        • et al.
        Association between the dose of dopaminergic medication and the behavioral disturbances in Parkinson disease.
        Parkinsonism Relat. Disord. 2010; 16: 202-207
        • Lim S.Y.
        • Tan Z.K.
        • Ngam P.I.
        • Lor T.L.
        • Mohamed H.
        • Schee J.P.
        • et al.
        Impulsive-compulsive behaviors are common in Asian Parkinson's disease patients: assessment using the QUIP.
        Parkinsonism Relat. Disord. 2011; 17: 761-764
        • Poletti M.
        • Logi C.
        • Lucetti C.
        • Del Dotto P.
        • Baldacci F.
        • Vergallo A.
        • et al.
        A single-center, cross-sectional prevalence study of impulse control disorders in Parkinson disease: association with dopaminergic drugs.
        J. Clin. Psychopharmacol. 2013; 33: 691-694
        • Callesen M.B.
        • Weintraub D.
        • Damholdt M.F.
        • Moller A.
        Impulsive and compulsive behaviors among Danish patients with Parkinson's disease: prevalence, depression, and personality.
        Parkinsonism Relat. Disord. 2014; 20: 22-26
        • Joutsa J.
        • Martikainen K.
        • Vahlberg T.
        • Voon V.
        • Kaasinen V.
        Impulse control disorders and depression in Finnish patients with Parkinson's disease.
        Parkinsonism Relat. Disord. 2012; 18: 155-160
        • Black D.W.
        A review of compulsive buying disorder.
        World Psychiatry. 2007; 6: 14-18
        • Derbyshire K.L.
        • Grant J.E.
        Compulsive sexual behavior: a review of the literature.
        J. Behav. Addict. 2015; 4: 37-43
        • Vitale C.
        • Santangelo G.
        • Erro R.
        • Errico D.
        • Manganelli F.
        • Improta I.
        • et al.
        Impulse control disorders induced by rasagiline as adjunctive therapy for Parkinson's disease: report of 2 cases.
        Parkinsonism Relat. Disord. 2013; 19: 483-484
        • Hassan A.
        • Bower J.H.
        • Kumar N.
        • Matsumoto J.Y.
        • Fealey R.D.
        • Josephs K.A.
        • et al.
        Dopamine agonist-triggered pathological behaviors: surveillance in the PD clinic reveals high frequencies.
        Parkinsonism Relat. Disord. 2011; 17: 260-264
        • Moore T.J.
        • Glenmullen J.
        • Mattison D.R.
        Reports of pathological gambling, hypersexuality, and compulsive shopping associated with dopamine receptor agonist drugs.
        JAMA Intern. Med. 2014; 174: 1930-1933
        • Antonini A.
        • Siri C.
        • Santangelo G.
        • Cilia R.
        • Poletti M.
        • Canesi M.
        • et al.
        Impulsivity and compulsivity in drug-naive patients with Parkinson's disease.
        Mov. Disord. 2011; 26: 464-468
        • Weintraub D.
        • Papay K.
        • Siderowf A.
        Screening for impulse control symptoms in patients with de novo Parkinson disease: a case-control study.
        Neurology. 2013; 80: 176-180
        • Voon V.
        • Fox S.H.
        Medication-related impulse control and repetitive behaviors in Parkinson disease.
        Arch. Neurol. 2007; 64: 1089-1096
        • Pontieri F.E.
        • Assogna F.
        • Pellicano C.
        • Cacciari C.
        • Pannunzi S.
        • Morrone A.
        • et al.
        Sociodemographic, neuropsychiatric and cognitive characteristics of pathological gambling and impulse control disorders NOS in Parkinson's disease.
        Eur. Neuropsychopharmacol. 2015; 25: 69-76
        • Bastiaens J.
        • Dorfman B.J.
        • Christos P.J.
        • Nirenberg M.J.
        Prospective cohort study of impulse control disorders in Parkinson's disease.
        Mov. Disord. 2013; 28: 327-333
        • Klos K.J.
        • Bower J.H.
        • Josephs K.A.
        • Matsumoto J.Y.
        • Ahlskog J.E.
        Pathological hypersexuality predominantly linked to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophy.
        Parkinsonism Relat. Disord. 2005; 11: 381-386
        • McKeon A.
        • Josephs K.A.
        • Klos K.J.
        • Hecksel K.
        • Bower J.H.
        • Michael Bostwick J.
        • et al.
        Unusual compulsive behaviors primarily related to dopamine agonist therapy in Parkinson's disease and multiple system atrophy.
        Parkinsonism Relat. Disord. 2007; 13: 516-519
        • Kim Y.Y.
        • Park H.Y.
        • Kim J.M.
        • Kim K.W.
        Pathological hypersexuality induced by dopamine replacement therapy in a patient with progressive supranuclear palsy.
        J. Neuropsychiatr. Clin. Neurosci. 2008; 20: 496-497
        • O'Sullivan S.S.
        • Djamshidian A.
        • Ahmed Z.
        • Evans A.H.
        • Lawrence A.D.
        • Holton J.L.
        • et al.
        Impulsive-compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy.
        Mov. Disord. 2010; 25: 638-642
        • Hughes A.J.
        • Daniel S.E.
        • Ben-Shlomo Y.
        • Lees A.J.
        The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service.
        Brain. 2002; 125: 861-870
        • Chesson Jr., A.L.
        • Wise M.
        • Davila D.
        • Johnson S.
        • Littner M.
        • Anderson W.M.
        • et al.
        Practice parameters for the treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Report. Standards of Practice Committee of the American Academy of Sleep Medicine.
        Sleep. 1999; 22: 961-968
        • Mackie S.
        • Winkelman J.W.
        Long-term treatment of Restless Legs Syndrome (RLS): an approach to management of worsening symptoms, loss of efficacy, and augmentation.
        CNS Drugs. 2015; 29: 351-357
        • Evans A.H.
        • Butzkueven H.
        Dopamine agonist-induced pathological gambling in restless legs syndrome due to multiple sclerosis.
        Mov. Disord. 2007; 22: 590-591
        • Tippmann-Peikert M.
        • Park J.G.
        • Boeve B.F.
        • Shepard J.W.
        • Silber M.H.
        Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists.
        Neurology. 2007; 68: 301-303
        • Cornelius J.R.
        • Tippmann-Peikert M.
        • Slocumb N.L.
        • Frerichs C.F.
        • Silber M.H.
        Impulse control disorders with the use of dopaminergic agents in restless legs syndrome: a case-control study.
        Sleep. 2010; 33: 81-87
        • Heim B.
        • Djamshidian A.
        • Heidbreder A.
        • Stefani A.
        • Zamarian L.
        • Pertl M.T.
        • Brandauer E.
        • Delazer M.
        • Seppi K.
        • Poewe W.
        • Högl B.
        Augmentation and impulsive behaviors in restless legs syndrome: Coexistence or association?.
        Neurology. 2016; 87: 36-40
        • Holman A.J.
        Impulse control disorder behaviors associated with pramipexole used to treat fibromyalgia.
        J. Gambl. Stud. 2009; 25: 425-431
        • Glezer A.
        • Bronstein M.D.
        Prolactinomas.
        Endocrinol. Metab. Clin. N. Am. 2015; 44: 71-78
        • Pahwa R.
        • Lyons K.E.
        Treatment of early Parkinson's disease.
        Curr. Opin. Neurol. 2014; 27: 442-449
        • Davie M.
        Pathological gambling associated with cabergoline therapy in a patient with a pituitary prolactinoma.
        J. Neuropsychiatry Clin. Neurosci. 2007; 19: 473-474
        • Martinkova J.
        • Trejbalova L.
        • Sasikova M.
        • Benetin J.
        • Valkovic P.
        Impulse control disorders associated with dopaminergic medication in patients with pituitary adenomas.
        Clin. Neuropharmacol. 2011; 34: 179-181
        • Bancos I.
        • Nannenga M.R.
        • Bostwick J.M.
        • Silber M.H.
        • Erickson D.
        • Nippoldt T.B.
        Impulse control disorders in patients with dopamine agonist-treated prolactinomas and nonfunctioning pituitary adenomas: a case-control study.
        Clin. Endocrinol. 2014; 80: 863-868
        • Tomlinson C.L.
        • Stowe R.
        • Patel S.
        • Rick C.
        • Gray R.
        • Clarke C.E.
        Systematic review of levodopa dose equivalency reporting in Parkinson's disease.
        Mov. Disord. 2010; 25: 2649-2653
        • Tamam L.
        • Bican M.
        • Keskin N.
        Impulse control disorders in elderly patients.
        Compr. Psychiatry. 2014; 55: 1022-1028
        • Moeller F.G.
        • Barratt E.S.
        • Dougherty D.M.
        • Schmitz J.M.
        • Swann A.C.
        Psychiatric aspects of impulsivity.
        Am. J. Psychiatry. 2001; 158: 1783-1793
        • Mendez M.F.
        Pathological stealing in dementia: poor response to SSRI medications.
        J. Clin. Psychiatry. 2011; 72: 418-419
        • Ozel-Kizil E.
        • Sakarya A.
        • Arica B.
        • Haran S.
        A case of frontotemporal dementia with amyotrophic lateral sclerosis presenting with pathological gambling.
        J. Clin. Neurol. (Seoul, Korea). 2013; 9: 133-137
        • Pompanin S.
        • Jelcic N.
        • Cecchin D.
        • Cagnin A.
        Impulse control disorders in frontotemporal dementia: spectrum of symptoms and response to treatment.
        Gen. Hosp. Psychiatry. 2014; 36: 760e5-7
        • Mendez M.F.
        • Shapira J.S.
        Hypersexual behavior in frontotemporal dementia: a comparison with early-onset Alzheimer's disease.
        Arch. Sex. Behav. 2013; 42: 501-509
        • Dagher A.
        • Robbins T.W.
        Personality, addiction, dopamine: insights from Parkinson's disease.
        Neuron. 2009; 61: 502-510
        • Koob G.F.
        • Volkow N.D.
        Neurocircuitry of addiction.
        Neuropsychopharmacology. 2010; 35: 217-238
        • Leroi I.
        • Ahearn D.J.
        • Andrews M.
        • McDonald K.R.
        • Byrne E.J.
        • Burns A.
        Behavioural disorders, disability and quality of life in Parkinson's disease.
        Age Ageing. 2011; 40: 614-621
        • Leroi I.
        • Harbishettar V.
        • Andrews M.
        • McDonald K.
        • Byrne E.J.
        • Burns A.
        Carer burden in apathy and impulse control disorders in Parkinson's disease.
        Int. J. Geriatr. Psychiatry. 2012; 27: 160-166