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Migraine affects 1 in 10 people worldwide featuring recent rise: A systematic review and meta-analysis of community-based studies involving 6 million participants

Published:December 02, 2016DOI:https://doi.org/10.1016/j.jns.2016.11.071

      Highlights

      • Global migraine prevalence is 11.6%; Africa 10.4%, Asia 10.1%, Europe 11.4%, North America 9.7%, and South America 16.4%.
      • Prevalence is 13.8% in females, 6.9% in males, 11.2% in urban residents, 8.4% in rural residents, and 12.4% in students.
      • There was a pattern of rising global migraine prevalence.
      • Higher student and urban affliction can lower academic and economic performance.
      • Improving awareness, early treatment, research, training, and healthy urban lifestyles may tackle this costly prevalence.

      Abstract

      Objective

      To study the weighted average global prevalence of migraine at the community level.

      Study design and setting

      A systematic review using advanced search strategies employing PubMed/MEDLINE, Scopus, and Web of Science was conducted for community-based and non-clinical studies by combining the terms “migraine”, “community-based”, and names of every country worldwide spanning all previous years from January 1, 1920 until August 31, 2015. Methods were in accordance with PRISMA and MOOSE guidelines. A meta-analysis with subgroup analysis was performed to identify pooled migraine prevalence and examine cohort heterogeneity.

      Results

      A total of 302 community-based studies involving 6,216,995 participants (median age 35 years, male-to-female ratio of 0.91) were included. Global migraine prevalence was 11.6% (95% CI 10.7–12.6%; random effects); 10.4% in Africa, 10.1% in Asia, 11.4% in Europe, 9.7% in North America, 16.4% in Central and South America. When the pooled cohort was stratified, the prevalence was 13.8% among females, 6.9% among males, 11.2% among urban residents, 8.4% among rural residents, and 12.4% among school/college students. Our result showed a pattern of rising global migraine prevalence.

      Conclusion

      Migraine affects one in ten people worldwide featuring recent rise. Higher prevalence was found among females, students, and urban residents.

      Keywords

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