Highlights
- •NMOsd patients with optic neuritis exhibited significantly lower BCVA values at all time points after attack than MS patients.
- •NMOsd patients with optic neuritis reached nadir earlier than MS patients.
- •NMOsd patients with optic neuritis regained a smaller fraction of baseline BCVA than MS patients.
- •Relapsed ON resulted in worse recovery in NMOsd, but not in MS.
Abstract
Background
Both neuromyelitis optica spectrum disorder (NMOsd) and multiple sclerosis (MS) patients
experience optic neuritis (ON) attacks characterized by rapidly reduced best-correct
visual acuity (BCVA) and slow recovery. Prognosis and effects of recurrence on recovery
may differ between disorders but remain unclear.
Objective
To compare ON severity, time and degree of recovery and effects of previous ON between
NMOsd and MS patients.
Methods
Retrospective chart review was performed. BCVA measurements acquired before ON, at
nadir and during recovery were retrospectively reviewed. Records were obtained on
69 ON attacks in 36 NMOsd patients and 43 attacks in 28 MS patients, including first
episodes and recurrences.
Results
NMOsd patients exhibited significantly lower BCVA values at all time points after
attack (P < 0.05), reached nadir earlier (P = 0.014) and regained a smaller fraction of baseline BCVA than MS patients (P < 0.001). In NMOsd, relapsed ON resulted in worse recovery and tended to reach nadir
earlier than first-episode ON (P = 0.030 and 0.059, respectively). In MS, relapsed ON also reached nadir earlier (P = 0.042); however, there was no difference in recovery.
Conclusions
Recovery from ON was poorer in NMOsd than in MS and was negatively affected by previous
ON attacks.
Keywords
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Article info
Publication history
Published online: June 17, 2016
Accepted:
June 16,
2016
Received in revised form:
June 15,
2016
Received:
January 24,
2016
Identification
Copyright
© 2016 Elsevier B.V. All rights reserved.
