Cerebral amyloid angiopathy (CAA) is a major cause of spontaneous lobar intracerebral haemorrhage (ICH) in older individuals [
]. Accurately predicting the risk of future ICH recurrence in CAA survivors, which is as high as 10–15% per year, is at the cornerstone of clinical care, with important implications for secondary prevention strategies, including antithrombotic drug use and blood pressure management [
- Boulouis G.
- Charidimou A.
- Greenberg S.M.
Sporadic cerebral amyloid angiopathy: pathophysiology, neuroimaging features, and clinical implications.
Seminars in neurology. 2016; 36: 233-243
]. CAA has been increasingly associated with characteristic MRI markers of small vessel damage which reveal intricate but distinct aspects of the disease process. Among these, the presence of multiple strictly lobar cerebral microbleeds is the most well characterised putative marker of CAA, facilitating diagnosis during life within the validated Boston criteria, and assessment of disease severity and progression [
- Charidimou A.
- Gang Q.
- Werring D.J.
Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum.
J. Neurol. Neurosurg. Psychiatry. 2012; 83: 124-137
]. However, beyond microbleeds, cortical superficial siderosis and MRI-visible perivascular spaces in the centrum semiovale (CSO-PVS) have recently emerged as additional promising neuroimaging signatures of CAA, potentially expanding the spectrum of this, as yet, untreatable disease.
- Pasquini M.
- Benedictus M.R.
- Boulouis G.
- Rossi C.
- Dequatre-Ponchelle N.
- Cordonnier C.
Incident cerebral microbleeds in a cohort of intracerebral hemorrhage.
Stroke. 2016; 47: 689-694
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- Sporadic cerebral amyloid angiopathy: pathophysiology, neuroimaging features, and clinical implications.Seminars in neurology. 2016; 36: 233-243
- Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum.J. Neurol. Neurosurg. Psychiatry. 2012; 83: 124-137
- Incident cerebral microbleeds in a cohort of intracerebral hemorrhage.Stroke. 2016; 47: 689-694
- Clinical Features of High-degree Centrum Semiovale-perivascular Spaces in Cerebral Amyloid Angiopathy.2016
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- Microbleeds versus macrobleeds: evidence for distinct entities.Stroke. 2009; 40: 2382-2386
- Dementia risk after spontaneous intracerebral haemorrhage: a prospective cohort study.Lancet Neurol. 2016;
- White matter perivascular spaces are related to cortical superficial siderosis in cerebral amyloid angiopathy.Stroke. 2014; 45: 2930-2935
Published online: June 07, 2016
Accepted: June 6, 2016
Received: June 4, 2016
© 2016 Elsevier B.V. All rights reserved.