Cerebral amyloid angiopathy (CAA) is a major cause of spontaneous lobar intracerebral
haemorrhage (ICH) in older individuals [
[1]
]. Accurately predicting the risk of future ICH recurrence in CAA survivors, which
is as high as 10–15% per year, is at the cornerstone of clinical care, with important
implications for secondary prevention strategies, including antithrombotic drug use
and blood pressure management [
[2]
]. CAA has been increasingly associated with characteristic MRI markers of small vessel
damage which reveal intricate but distinct aspects of the disease process. Among these,
the presence of multiple strictly lobar cerebral microbleeds is the most well characterised
putative marker of CAA, facilitating diagnosis during life within the validated Boston
criteria, and assessment of disease severity and progression [
[3]
]. However, beyond microbleeds, cortical superficial siderosis and MRI-visible perivascular
spaces in the centrum semiovale (CSO-PVS) have recently emerged as additional promising
neuroimaging signatures of CAA, potentially expanding the spectrum of this, as yet,
untreatable disease.Keywords
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Article info
Publication history
Published online: June 07, 2016
Accepted:
June 6,
2016
Received:
June 4,
2016
Identification
Copyright
© 2016 Elsevier B.V. All rights reserved.
