Highlights
- •3D black blood T1-weighted sequence (T1 SPACE) at 3 T was performed for the patients.
- •T1 SPACE was helpful in the diagnosis of subacute cerebral venous thrombosis.
- •T1 SPACE offered excellent visualization of the thrombus as evident high signal intensity.
- •The sensibility/specificity for T1 SPACE were 100%/100% per patient and 96.7%/100% per segment.
Abstract
Background
We investigated the value of 3D T1-weighted SPACE (Sampling Perfection with Application
optimized Contrast using different angle Evolutions, a 3D fast spin echo black blood
sequence) in the diagnosis of cerebral venous thrombosis (CVT).
Methods
We prospectively included 31 consecutive patients who were suspected as having a CVT
within one month of disease onset. The reference standard of CVT diagnosis was based
on all of the conventional imaging tests (including susceptibility weighted imaging),
clinical information, and prognosis information.
Results
The final diagnosis of the CVT was made for 14 patients including 60 venous segments.
The median time between disease onset and the examination with magnetic resonance
was 12.5 days with a range of 8 to 27 days. The diagnosis results of susceptibility weighted imaging plus magnetic resonance
venography (MRV) were consistent with the final diagnosis. The sensibility/specificity
for T1 SPACE were 100%/100% per patient and 96.7%/100% per segment. The area under
the curve based on patient for T1 SPACE was higher than that of standard magnetic
resonance imaging (MRI) (1.0 vs. 0.80, P = 0.02) and standard MRI plus MRV (1.0 vs. 0.91, P = 0.14). The area under the curve based on segment for T1 SPACE was significant higher
than that of standard MRI (0.98 vs. 0.81, P < 0.001) and standard MRI plus MRV (0.98 vs. 0.87, P < 0.001).
Conclusions
3D T1 SPACE offered excellent visualization of the thrombus as evident high signal
intensity with an acceptable acquisition time. The use of 3D T1 SPACE may improve
the accuracy of subacute CVT diagnosis.
Abbreviations:
CT (computed tomography), CVT (Cerebral venous thrombosis), FSE (fast spin echo), MRI (magnetic resonance imaging), MRV (magnetic resonance venography), SPACE (Sampling Perfection with Application optimized Contrast using different angle Evolutions), SWI (susceptibility weighted imaging)Keywords
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References
- Cerebral venous thrombosis: an update.Lancet Neurol. 2007; 6: 162-170
- Cerebral venous sinus thrombosis: update on diagnosis and management.Curr Cardiol Rep. 2014; 16: 523
- Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association.Stroke. 2011; 42: 1158-1192
- 3D fast spin-echo T1 black-blood imaging for the diagnosis of cervical artery dissection.AJNR Am. J. Neuroradiol. 2013; 34: E103-E106
- 3D fat-saturated T1 SPACE sequence for the diagnosis of cervical artery dissection.Neuroradiology. 2013; 55: 595-602
- Early detection and quantification of cerebral venous thrombosis by magnetic resonance black-blood thrombus imaging.Stroke. 2015; 47: 404-409
- STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies.Radiology. 2015; 277: 826-832
- Diagnostic value of T2*-weighted gradient-echo MRI for segmental evaluation in cerebral venous sinus thrombosis.Clin. Imaging. 2015; 39: 15-19
- The measurement of observer agreement for categorical data.Biometrics. 1977; 33: 159-174
- Cervical-artery dissections: predisposing factors, diagnosis, and outcome.Lancet Neurol. 2009; 8: 668-678
- Radiological findings in cerebral venous thrombosis presenting as subarachnoid hemorrhage: a series of 22 cases.Neuroradiology. 2015; 58: 11-16
- Susceptibility-weighted imaging in the diagnosis of isolated cortical vein thrombosis.Eur. Neurol. 2014; 71: 57-58
- Susceptibility-weighted imaging: technical aspects and clinical applications, part 2.AJNR Am. J. Neuroradiol. 2009; 30: 232-252
- MRI of clot in cerebral venous thrombosis: high diagnostic value of susceptibility-weighted images.Stroke. 2006; 37: 991-995
- MRI diagnosis of dural sinus - cortical venous thrombosis: immediate post-contrast 3D GRE T1-weighted imaging versus unenhanced MR venography and conventional MR sequences.Clin. Neurol. Neurosurg. 2015; 134: 44-54
- Improved black-blood imaging using DANTE-SPACE for simultaneous carotid and intracranial vessel wall evaluation.Magn. Reson. Med. 2015; (Epub ahead of print)https://doi.org/10.1002/mrm.25785
Article info
Publication history
Published online: May 27, 2016
Accepted:
May 25,
2016
Received in revised form:
May 11,
2016
Received:
March 1,
2016
Identification
Copyright
© 2016 Elsevier B.V. All rights reserved.
