Highlights
- •Clinicians tend to focus on neurologic deficits only in pwMS and prefer to prescribe rehabilitation programs to counteract these deficits.
- •This review shows that pwMS also experience muscular, cardiac, ventilatory and metabolic dysfunction, which might contribute to exercise intolerance.
- •The impact of exercise intervention on these anomalies in MS patients are mostly unknown.
- •It is suggested that MS patients should be screened systematically for muscular, cardiac, ventilatory and metabolic function.
Abstract
In the treatment of multiple sclerosis (MS), exercise training is now considered a
cornerstone. However, most clinicians tend to focus on neurologic deficits only, and
thus prefer to prescribe rehabilitation programs specifically to counteract these
deficits. However, the present comprehensive review shows that patients with MS (pwMS)
also experience significant muscular, cardiac, ventilatory and metabolic dysfunction,
which significantly contribute, next to neurologic deficits, to exercise intolerance.
In addition, these anomalies also might increase the risk for frequent hospitalization
and morbidity and can reduce life expectancy. Unfortunately, the impact of exercise
intervention on these anomalies in pwMS are mostly unknown. Therefore, it is suggested
that pwMS should be screened systematically for muscular, cardiac, ventilatory and
metabolic function during exercise testing. The detection of such anomalies should
lead to adaptations and optimisation of exercise training prescription and clinical
care/medical treatment of pwMS. In addition, future studies should focus on the impact
of exercise intervention on muscular, cardiac, ventilatory and metabolic (dys)function
in pwMS, to contribute to improved treatment and care.
Keywords
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Article info
Publication history
Published online: May 25, 2016
Accepted:
May 24,
2016
Received in revised form:
May 11,
2016
Received:
August 3,
2015
Identification
Copyright
© 2016 Elsevier B.V. All rights reserved.
