Highlights
- •We analyzed the relationship between SNCA SNPs and DNA methylation status, mRNA expression in PBMCs of PD patients and controls
- •Hypomethylation of SNCA was detected in PBMCs of PD patients and associated with rs3756063 polymorphism
- •SNCA mRNA levels were not associated with disease status, rs3756063 polymorphism or DNA methylation of SNCA
Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Genome-wide
association studies have confirmed the association of single nucleotide polymorphisms
(SNPs) located in the SNCA gene with the risk of PD. While hypomethylation of the SNCA intron-1 was observed in patients with sporadic PD, an association between SNCA SNPs and SNCA methylation levels has been identified. To investigate whether these SNPs are associated
with the level of SNCA methylation in the Chinese population, we genotyped SNCA SNPs and analyzed the relationship between SNCA SNPs and SNCA DNA methylation status from peripheral blood mononuclear cells of Chinese Han PD
patients. Our results revealed that the rs3756063 polymorphism could contribute to
the risk of PD in the Chinese Han population and confirmed the effect of this polymorphism
on SNCA DNA methylation. Further studies will be needed to gain a better understanding of
the mechanisms underlying the associations between SNPs, methylation and PD pathogenesis.
Keywords
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Article info
Publication history
Published online: May 19, 2016
Accepted:
May 18,
2016
Received in revised form:
May 4,
2016
Received:
November 25,
2015
Identification
Copyright
© 2016 Elsevier B.V. All rights reserved.
