Highlights
- •Vitamin D levels are not predictors of survival in Korean ALS patients.
- •To elucidate the role of vitamin D on ALS, its free-form needs to be measured.
- •Bone mineral density is a better marker for bone health in Korean ALS patients.
- •Older age at onset and bulbar onset are consistently poor prognostic factors.
Abstract
Objective
This study aimed to measure serum 25-hydroxyvitamin D [25(OH)D] concentrations, bone
mineral density (BMD), and the parameters of bone metabolism in amyotrophic lateral
sclerosis (ALS) patients, and their correlation with survival.
Methods
We retrospectively analysed data of 100 ALS patients who consecutively visited a single
referral ALS clinic between January and December 2011. Sex; age and site of symptom
onset; and death were recorded. Serum 25(OH)D concentration was dichotomized as <10 ng/ml and ≥10 ng/ml.
Results
There was absent relationship between serum 25(OH)D and concentration of bone turnover
parameters or between 25(OH)D and BMD. According to the results of the Kaplan–Meier
analysis with log-rank test, the survival rates of patients without (≥10 ng/ml) and of those with severe vitamin D deficiency (< 10ng/ml) were not significantly different. Cox regression analysis showed that a poor
prognosis was most correlated with older age at onset and bulbar onset after adjustment
for all the clinical factors.
Conclusions
In conclusion, vitamin D levels were not correlated to other bone markers and survival
in a clinic population of ALS patients.
Keywords
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Article info
Publication history
Published online: May 06, 2016
Accepted:
May 5,
2016
Received in revised form:
April 28,
2016
Received:
March 10,
2016
Identification
Copyright
© 2016 Elsevier B.V. All rights reserved.
