Highlights
- •Gut microbiota was associated with subsequent relapse risk in pediatric multiple sclerosis.
- •Fusobacteria depletion increased relapse risk (hazard ratio = 3.2; 95% CI: 1.2–9.0).
- •Findings could offer new targets to alter the MS disease course.
Abstract
We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing
of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse
over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion
(p = 0.001 log-rank test), expansion of the Firmicutes (p = 0.003), and presence of the Archaea Euryarchaeota (p = 0.037). After covariate adjustments for age and immunomodulatory drug exposure, only
absence (vs. presence) of Fusobacteria was associated with relapse risk (hazard ratio = 3.2 (95% CI: 1.2–9.0), p = 0.024). Further investigation is warranted. Findings could offer new targets to alter
the MS disease course.
Keywords
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Article info
Publication history
Published online: February 20, 2016
Accepted:
February 16,
2016
Received in revised form:
February 11,
2016
Received:
January 4,
2016
Footnotes
☆Statistical analyses were performed by Helen Tremlett (University of British Columbia).
Identification
Copyright
© 2016 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
