Advertisement

Gut microbiota composition and relapse risk in pediatric MS: A pilot study

Published:February 20, 2016DOI:https://doi.org/10.1016/j.jns.2016.02.042

      Highlights

      • Gut microbiota was associated with subsequent relapse risk in pediatric multiple sclerosis.
      • Fusobacteria depletion increased relapse risk (hazard ratio = 3.2; 95% CI: 1.2–9.0).
      • Findings could offer new targets to alter the MS disease course.

      Abstract

      We explored the association between baseline gut microbiota (16S rRNA biomarker sequencing of stool samples) in 17 relapsing-remitting pediatric MS cases and risk of relapse over a mean 19.8 months follow-up. From the Kaplan-Meier curve, 25% relapsed within an estimated 166 days from baseline. A shorter time to relapse was associated with Fusobacteria depletion (p = 0.001 log-rank test), expansion of the Firmicutes (p = 0.003), and presence of the Archaea Euryarchaeota (p = 0.037). After covariate adjustments for age and immunomodulatory drug exposure, only absence (vs. presence) of Fusobacteria was associated with relapse risk (hazard ratio = 3.2 (95% CI: 1.2–9.0), p = 0.024). Further investigation is warranted. Findings could offer new targets to alter the MS disease course.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Berer K.
        • Mues M.
        • Koutrolos M.
        • et al.
        Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.
        Nature. 2011; 479: 538-541
        • Lee Y.K.
        • Menezes J.S.
        • Umesaki Y.
        • Sarkis K.
        • Mazmaniana S.K.
        Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis.
        Proc. Natl. Acad. Sci. U. S. A. 2011; 108: 4615-4622
        • Mielcarz D.W.
        • Kasper L.H.
        The gut microbiome in multiple sclerosis.
        Curr. Treat. Options Neurol. 2015 Apr; 17: 344https://doi.org/10.1007/s11940-015-0344-7
        • Ochoa-Reparaz J.
        • Mielcarz D.W.
        • Ditrio L.E.
        • Burroughs A.R.
        • Begum-Haque S.
        • Dasgupta S.
        • et al.
        Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.
        J. Immunol. 2010; 185: 4101-4108
        • Tremlett H.
        • Fadrosh D.W.
        • Faruqi A.A.
        • et al.
        Gut microbiota in early pediatric multiple sclerosis: a case–control study.
        Date: 2016
        (under review)
        • Miyake S.
        • Kim S.
        • Suda W.
        • Oshima K.
        • Nakamura M.
        • Matsuoka T.
        • et al.
        Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters.
        PLoS ONE. 2015; 10e0137429
        • Cantarel B.L.
        • Waubant E.
        • Chehoud C.
        • Kuczynski J.
        • DeSantis T.Z.
        • Warrington J.
        • et al.
        Gut microbiota in multiple sclerosis: possible influence of immunomodulators.
        J. Investig. Med. 2015; 63: 729-734
        • Rumah K.R.
        • Linden J.
        • Fischetti V.A.
        • Vartanian T.
        Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease.
        PLoS ONE. 2013; 8e76359
        • DeAngelis K.M.
        • et al.
        Selective progressive response of soil microbial community to wild oat roots.
        ISME J. 2009; 3: 168-178
        • Caporaso J.G.
        • Lauber C.L.
        • Walters W.A.
        • et al.
        Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms.
        ISME J. 2012; 6: 1621-1624
        • Caporaso J.G.
        • Kuczynski J.
        • Stombaugh J.
        • et al.
        QIIME allows analysis of high-throughput community sequencing data.
        Nat. Methods. 2010; 7: 335-336
        • López-Cepero A.A.
        • Palacios C.
        Association of the intestinal microbiota and obesity.
        P. R. Health Sci. J. 2015; 34: 60-64
        • Suchodolski J.S.
        • Dowd S.E.
        • Wilke V.
        • Steiner J.M.
        • Jergens A.E.
        16S rRNA gene pyrosequencing reveals bacterial dysbiosis in the duodenum of dogs with idiopathic inflammatory bowel disease.
        PLoS ONE. 2012; 7: e39333
        • Mima K.
        • Nishihara R.
        • Qian Z.R.
        • et al.
        Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.
        Gut. 2015; ([Epub ahead of print])https://doi.org/10.1136/gutjnl-2015-310101
        • Kingwell E.
        • Bajdik C.
        • Phillips N.
        • et al.
        Cancer risk in multiple sclerosis: findings from British Columbia, Canada.
        Brain. 2012; 135: 2973-2979