Cognition, mood, and purpose in life in neuromyelitis optica spectrum disorder

Published:January 11, 2016DOI:


      • Cognitive impairment was detected in subjects with NMOSD.
      • Low purpose in life was associated with cognitive impairment in NMOSD.
      • Higher rates of depression were observed in subjects with NMOSD.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Mealy M.A.
        • et al.
        Epidemiology of neuromyelitis optica in the United States: a multicenter analysis.
        Arch. Neurol. 2012; 69: 1176-1180
        • Wingerchuk D.M.
        • et al.
        International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.
        Neurology. 2015;
        • Blanc F.
        • et al.
        White matter atrophy and cognitive dysfunctions in neuromyelitis optica.
        PLoS ONE. 2012; 7: e33878
        • Rocca M.A.
        • et al.
        Magnetization transfer and diffusion tensor MRI show gray matter damage in neuromyelitis optica.
        Neurology. 2004; 62: 476-478
        • Yu C.S.
        • et al.
        Diffusion tensor imaging in the assessment of normal-appearing brain tissue damage in relapsing neuromyelitis optica.
        AJNR Am. J. Neuroradiol. 2006; 27: 1009-1015
        • Blanc F.
        • et al.
        Cognitive functions in neuromyelitis optica.
        Arch. Neurol. 2008; 65: 84-88
        • Saji E.
        • et al.
        Cognitive impairment and cortical degeneration in neuromyelitis optica.
        Ann. Neurol. 2013; 73: 65-76
        • Borden A.
        • et al.
        Depression and Devic's syndrome.
        Am. J. Psychiatry. 2004; 161: 1128
        • Marrie R.A.
        • et al.
        The incidence and prevalence of psychiatric disorders in multiple sclerosis: a systematic review.
        Mult. Scler. 2015; 21: 305-317
        • Mrabet S.
        • et al.
        Depression in multiple sclerosis.
        Rev. Neurol. (Paris). 2014; 170: 700-702
        • He D.
        • et al.
        Cognitive function, depression, fatigue, and activities of daily living in patients with neuromyelitis optica after acute relapse.
        Int. J. Neurosci. 2011; 121: 677-683
        • Qian P.
        • et al.
        Association of neuromyelitis optica with severe and intractable pain.
        Arch. Neurol. 2012; 69: 1482-1487
        • Vanotti S.
        • et al.
        Cognitive performance of neuromyelitis optica patients: comparison with multiple sclerosis.
        Arq. Neuropsiquiatr. 2013; 71: 357-361
        • Crumbaugh J.C.
        • Maholick L.T.
        An experimental study in existentialism: the psychometric approach to Frankl's concept of noogenic neurosis.
        J. Clin. Psychol. 1964; 20: 200-207
        • Jonsen E.
        • et al.
        Psychometric properties of the Swedish version of the Purpose in Life scale.
        Scand. J. Caring Sci. 2010; 24: 41-48
        • Boyle P.A.
        • et al.
        Effect of a purpose in life on risk of incident Alzheimer disease and mild cognitive impairment in community-dwelling older persons.
        Arch. Gen. Psychiatry. 2010; 67: 304-310
        • Boyle P.A.
        • Buchman A.S.
        • Bennett D.A.
        Purpose in life is associated with a reduced risk of incident disability among community-dwelling older persons.
        Am. J. Geriatr. Psychiatr. 2010; 18: 1093-1102
        • Kim E.S.
        • et al.
        Purpose in life and reduced incidence of stroke in older adults: ‘The Health and Retirement Study’.
        J. Psychosom. Res. 2013; 74: 427-432
        • Yu L.
        • et al.
        Purpose in life and cerebral infarcts in community-dwelling older people.
        Stroke. 2015; 46: 1071-1076
        • Kim E.S.
        • et al.
        Purpose in life and reduced risk of myocardial infarction among older U.S. adults with coronary heart disease: a two-year follow-up.
        J. Behav. Med. 2013; 36: 124-133
        • Hooker S.A.
        • Masters K.S.
        Purpose in life is associated with physical activity measured by accelerometer.
        J. Health Psychol. 2014;
        • Konkoly Thege B.
        • et al.
        Relationship between meaning in life and smoking status: results of a national representative survey.
        Addict. Behav. 2009; 34: 117-120
        • Kim E.S.
        • Strecher V.J.
        • Ryff C.D.
        Purpose in life and use of preventive health care services.
        Proc. Natl. Acad. Sci. U. S. A. 2014; 111: 16331-16336
        • Lathan C.
        • et al.
        Defense Automated Neurobehavioral Assessment (DANA)-psychometric properties of a new field-deployable neurocognitive assessment tool.
        Mil. Med. 2013; 178: 365-371
        • Kocalevent R.D.
        • Hinz A.
        • Brahler E.
        Standardization of the depression screener patient health questionnaire (PHQ-9) in the general population.
        Gen. Hosp. Psychiatry. 2013; 35: 551-555
        • Pereira W.L.
        • et al.
        Epidemiological, clinical, and immunological characteristics of neuromyelitis optica: a review.
        J. Neurol. Sci. 2015;
        • Zimmerman M.
        Symptom severity and guideline-based treatment recommendations for depressed patients: implications of DSM-5's potential recommendation of the PHQ-9 as the measure of choice for depression severity.
        Psychother. Psychosom. 2012; 81: 329-332
        • Benedict R.H.
        • et al.
        Reliability and equivalence of alternate forms for the Symbol Digit Modalities Test: implications for multiple sclerosis clinical trials.
        Mult. Scler. 2012; 18: 1320-1325
        • Van Schependom J.
        • et al.
        The Symbol Digit Modalities Test as sentinel test for cognitive impairment in multiple sclerosis.
        Eur. J. Neurol. 2014; 21 (e71-2): 1219-1225
        • Zhang N.
        • et al.
        Cognitive impairment in Chinese neuromyelitis Ooptica.
        Mult Scler. 2015;
        • He D.
        • et al.
        Cognitive impairment and whole brain diffusion in patients with neuromyelitis optica after acute relapse.
        Brain Cogn. 2011; 77: 80-88
        • Scullin M.K.
        • Bliwise D.L.
        Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research.
        Perspect. Psychol. Sci. 2015; 10: 97-137
        • Sjonnesen K.
        • et al.
        Evaluation of the 9-item Patient Health Questionnaire (PHQ-9) as an assessment instrument for symptoms of depression in patients with multiple sclerosis.
        Postgrad. Med. 2012; 124: 69-77
        • Chruzander C.
        • et al.
        A 10-year follow-up of a population-based study of people with multiple sclerosis in Stockholm, Sweden: changes in disability and the value of different factors in predicting disability and mortality.
        J. Neurol. Sci. 2013; 332: 121-127
        • Nielsen-Prohl J.
        • et al.
        Stress-stimulated volitional coping competencies and depression in multiple sclerosis.
        J. Psychosom. Res. 2013; 74: 221-226
        • Medina A.B.
        • et al.
        Update of sleep alterations in depression.
        Sleep Sci. 2014; 7: 165-169
        • Boyle P.A.
        • et al.
        Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age.
        Arch. Gen. Psychiatry. 2012; 69: 499-505
        • Kawahara Y.
        • et al.
        Cognitive and affective assessments of multiple sclerosis (MS) and neuromyelitis optica (NMO) patients utilizing computerized touch panel-type screening tests.
        Intern. Med. 2014; 53: 2281-2290
        • Liu Y.
        • et al.
        Structural MRI substrates of cognitive impairment in neuromyelitis optica.
        Neurology. 2015; 85: 1491-1499