Highlights
- •Cytokines play important roles in the inflammation pathways.
- •Alzheimer's (AD) is an inflammatory disease, and cytokines are able to influence AD.
- •We investigated the association of IL16 polymorphisms with risk of AD in an Iranian population.
- •IL16 rs4072111 polymorphism was associated with susceptibility to AD in an Iranian population.
Abstract
Cytokines play important roles in the inflammation pathways. Alzheimer's disease (AD)
is an inflammatory disease, and it is suggested that cytokines are able to influence
AD. We investigated the association between IL16 polymorphisms and risk of AD in an Iranian population. The case group consisted of
144 individuals with AD and the control group included 173 healthy individuals. Genotyping
of the IL16 rs4072111 C > T and rs1131445 T > C polymorphisms was determined using PCR-RFLP method. The frequency of rs4072111 CT
genotype was significantly lower (P = 0.007; OR = 0.5, 95% CI: 0.3–0.8) in the patients (17.3%) than the control group (30%). The rs4072111
T allele was significantly lower (P = 0.008; OR = 0.5, 95% CI: 0.3–0.9) in the cases (8.6%) compared with the control group (15.6%).
The IL16 rs4072111 polymorphism may be associated with susceptibility to AD and the T allele
may have a protective role in the progression of AD in an Iranian population.
Keywords
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References
- Alzheimer's disease with asymmetric parietal lobe atrophy: a case report.J. Neurol. Sci. 1998; 160: 96-99
- Inflammatory processes in Alzheimer's disease.J. Neuroimmunol. 2007; 184: 69-91
- Neuroimaging diagnosis in neurodegenerative diseases.Nucl. Med. Rev. Cent. East. Eur. 2010; 13: 23-31
- No association of the HLA-A2 allele with Alzheimer's disease.Neurosci. Lett. 2002; 335: 75-78
- Molecular biology and genetics of Alzheimer's disease.C. R. Biol. 2005; 328: 119-130
- Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease.J. Neurovirol. 1999; 5: 32-41
- Global prevalence of dementia: a Delphi consensus study.Lancet. 2005; 366: 2112-2117
- Alzheimer's disease: one disorder, too many genes?.Hum. Mol. Genet. 2004; 1: R135-R141
- New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists.Ann. N. Y. Acad. Sci. 2004; 1035: 290-315
- Processing and activation of pro-interleukin-16 by caspase-3.J. Boil. Chem. 1998; 273: 1144-1149
- Human focal cerebral infarctions induce differential lesional interleukin-16 (IL-16) expression confined to infiltrating granulocytes, CD8+ T-lymphocytes and activated microglia⁄macrophages.J. Neuroimmunol. 2001; 114: 232-241
- Chitotriosidase and inflammatory mediator levels in Alzheimer's disease and cerebrovascular dementia.Eur. J. Neurosci. 2006; 23: 2648-2656
- A simple salting out procedure for extracting DNA from human nucleated cells.Nucleic Acids Res. 1988; 11: 1215
- Role of genes and environments for explaining Alzheimer disease.Arch. Gen. Psychiatry. 2006; 63: 168-174
- Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease.Neurobiol. Aging. 2015; 36: 60-67
- Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.Hum. Mol. Genet. 2008; 17: 759-767
- Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.Nat. Protoc. 2009; 4: 1073-1081
- The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer.Carcinogenesis. 2009; 30: 295-299
- Interleukin-16 polymorphism is associated with an increased risk of glioma.Genet. Test. Mol. Biomarkers. 2014; 18: 711-714
Article info
Publication history
Published online: September 11, 2015
Accepted:
September 10,
2015
Received in revised form:
August 30,
2015
Received:
April 17,
2015
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
