Highlights
- •Eighty one PD, 34 MSA patients and 16 normal controls were enrolled in our study.
- •Three studies were included in the present meta-analysis.
- •Middle cerebellar peduncle (MCP) width is significantly smaller in MSA than PD.
- •Disease duration correlated with MCP width in PD without tremor onset.
- •Our meta-analysis also indicated the reduction of MCP width in MSA relative to PD.
Abstract
The majority of studies of Parkinson's disease (PD) focused on basal ganglia initially;
however, accumulating evidence suggests cerebellar involvement in pathophysiology.
We aimed to investigate the effects of tremor onset on middle cerebellar peduncle
(MCP) width of PD patients and of disease duration on differential diagnosis. We measured
MCP width of 81 PD, 34 multiple system atrophy (MSA) and 16 normal controls, using
MRI. A meta-analysis was performed including two previous and the present studies.
We carried out correlation analysis between disease duration and MCP width separately
in subgroup of PD with or without tremor onset. Receiver operating characteristic
curves were analyzed. Our meta-analysis indicated that MCP width was significantly
smaller in MSA relative to PD with homogeneous studies. There was significant correlation
between disease duration and MCP width in PD without tremor onset. In contrast, there
was no correlation observed in PD with tremor onset. Subclassification according to
disease duration showed improved area under curve of PD vs. MSA with predominant parkinsonian
features. MCP width could be a valuable tool for differential diagnosis. Our finding
suggested that MCP was impaired in advanced stage of PD without tremor onset as part
of the abnormality of the cerebellar system.
Keywords
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Article info
Publication history
Published online: August 26, 2015
Accepted:
August 25,
2015
Received in revised form:
August 7,
2015
Received:
April 21,
2015
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
