Abstract|Stroke 1| Volume 357, SUPPLEMENT 1, e99, October 15, 2015

The impact of genetic polymorphisms on efficacy of aspirin in ischemic stroke patients in China

      Background & objectives: Little research regarding genotypes and aspirin response related to acute ischemic stroke has been published. This study was conducted to investigate whether the polymorphisms affect aspirin response and prognosis related to acute stroke.
      Methods: A total of 752 patients with acute ischemic stroke were enrolled in this study; all received follow-up evaluations 3, 6 and 12 months after aspirin treatment. rs1045642, rs868853, rs1330344, rs20417, rs12041331, and rs2768759 were screened. The arachidonic acid (AA)-induced and adenosine diphosphate-induced (ADP) platelet aggregation test, the National Institutes of Health Stroke Scale (NIHSS), and the modified Rankin Scale (mRS) were used, and blood vascular events were evaluated.
      Results: The difference before and after aspirin treatment on AA-induced platelet aggregation was significantly smaller in patients carrying rs12041331G alleles compared with patients carrying none. Patients with none had better outcomes demonstrated by NIHSS and mRS scores after treatment.
      Conclusion: rs12041331 genotypes had a significant impact on aspirin response and prognosis of patients with stroke.