Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by multifactorial etiology, affections of central and peripheral motor neurons, progressive course and onset of terminal respiratory insufficiency. The amount of patients including ones in Uzbekistan that are suffering and dying from ALS is increasing. The development of a familial ALS (FALS) shows the role of mutations of the gene producing the superoxide dismutase 1.
Data on morbidity of ALS on base of register for the period of 2013–2014 was studied. Special attention was paid to geographic epidemiology of ALS in different regions of Uzbekistan and to features of clinical manifestations of this disease in Uzbek nationality.
During the analyzed period there were 3.4 cases of ALS per 100,000 per year registered. 70% were patients from Andijan valley, 30% fromother regions. Gender analysis determined that 60% of patients were women (mean age 43 ± 4.2 years), 40% men (mean age 48 ± 3.4 years). Most patients associated the debut of ALS with virus disease. Disease of 80% of patients debuted by bulbar form, of 20% by spinal form. The FALS is absent in our country. The average life expectancy was 2.5 ± 0.45 years during the bulbar form and 3 ± 0.86 years during the spinal form. The onset of decompensation period on the average 6 month later after debut.
The analysis of the register of ALS in Uzbekistan demonstrated that ALS was the most common disease in Andijan valley, primary occurred in women, is not of a personal nature and mainly declares itself by bulbar form.
© 2015 Published by Elsevier Inc.