Correlation between EDSS and cognitive decline in patients with multiple sclerosis. Pilot study of bicams version in a Brazilian population

      Background: Just like physical disability, the cognitive impairment occurs in a distressing form the patients with Multiple Sclerosis (MS). In addition to the routine approach to physical impairment, it is essential that a methodic and operational neuropsychological assessment be used, which definitely contributes in qualifying care of these patients. Reliable, validated and quick and easy applicable Neuropsychological Tests (TN) by Neurologist in routine visits, are essential tools for follow-up and to detect the need for future therapeutic intervention.
      Objective: To investigate the correlation between clinical status of MS patients, measured by the EDSS, and the TN battery of BICAMS (International Brief Cognitive Assessment for Multiple Sclerosis).
      Patients and Methods: Fourteen patients with a definitive diagnosis of Relapsing - Remitting MS (RRMS) were included. The results of the EDSS and TN of BICAMS (SDMT, CVLT-II and the BVMT) were obtained retrospectively from medical records of patients included. Pearson correlation coefficients (r) and coefficient of determination (r 2) were used to estimate the linear association between the variables. All included patients agreed to participate signed previously an Informed Consent Term.
      Results: There was a great magnitude correlation between the EDSS, SDMT and BVMT, with r = 0.69 and 0.75 (p<0.05), respectively. Although not reaching significance criteria, the EDSS and CVLT relationship was moderate and clinically substantial.
      Conclusion: The Brazilian version of BICAMS seems to be of easy and satisfactory implementation in routine visit by Neurologists and presents clinically significant correlation with the EDSS. Future studies with wide extension should replicate these initial findings.