Highlights
- •TC, FBG,WHR, hypertension, and negative events may be associated with the risk of IS in Chinese Uyghur population.
- •The PPARδC allele genotype was less frequent in Chinese Uyghur, Germany, Caucasian and Sweden populations than in Han population.
- •The PPARδ+294C allele maybe an independent risk of IS in Chinese Uyghurs especially in the male and obesity populations.
Abstract
PPARδ belongs to a receptor family of ligand-activated transcription factors involved
in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis
and endothelial cell function. Through these effects, they might be involved with
the ischemic stroke (IS). We recruited 200 subjects (100 IS patients diagnosed by
CTs or/and magnetic resonance imaging (MRI) and 100 normal healthy controls from Chinese
Uyghur population) to assess the nature of the functional polymorphisms of PPARδ +294T/C and any links with IS in this unique population. We found that the C allele
of the PPARδ +294T/C polymorphism was more common in controls than IS subjects in the Uyghur population.
C allele carriage may be associated with an increased risk of IS in Uyghurs with a
strong trend (OR 1.79, 95% CI: 1.11–2.89). Additionally, the PPARδ CC and TC genotypes
were less frequent in Uyghur population than in Han population. Our population and
ethnic-based study demonstrates that the PPARδ +294C allele maybe an independent risk of IS in Chinese Uyghurs especially in the male
(OR 1.99, 95%CI:1.06–3.72) and obesity populations (OR 2.36, 95%CI: 1.19–4.67), which
were consistent with Tunisian Population. Moreover, total cholesterol, fasting blood
glucose, waist-to-hip ratio, hypertension, history of heart diseases, and negative
events may increase the risk of IS, with a trend for HDL to be a protective factor
for IS in the Uyghur population. However, larger populations are warranted to validate
our findings.
Abbreviations:
PPARδ (Peroxisome Proliferator-Activated Receptor Delta), IS (Ischemic stroke), BMI (Body Mass Index), WHR (Waist Hip Ratio), FBG (Fasting blood glucose), TC (Total cholesterol), TG (Triglyceride), OR (Odds ratio), CI (Confidence interval)Keywords
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Article info
Publication history
Published online: August 17, 2015
Accepted:
August 14,
2015
Received in revised form:
August 12,
2015
Received:
July 9,
2015
Identification
Copyright
© 2015 Published by Elsevier Inc. All rights reserved.
