- •TC, FBG,WHR, hypertension, and negative events may be associated with the risk of IS in Chinese Uyghur population.
- •The PPARδC allele genotype was less frequent in Chinese Uyghur, Germany, Caucasian and Sweden populations than in Han population.
- •The PPARδ+294C allele maybe an independent risk of IS in Chinese Uyghurs especially in the male and obesity populations.
PPARδ belongs to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. Through these effects, they might be involved with the ischemic stroke (IS). We recruited 200 subjects (100 IS patients diagnosed by CTs or/and magnetic resonance imaging (MRI) and 100 normal healthy controls from Chinese Uyghur population) to assess the nature of the functional polymorphisms of PPARδ +294T/C and any links with IS in this unique population. We found that the C allele of the PPARδ +294T/C polymorphism was more common in controls than IS subjects in the Uyghur population. C allele carriage may be associated with an increased risk of IS in Uyghurs with a strong trend (OR 1.79, 95% CI: 1.11–2.89). Additionally, the PPARδ CC and TC genotypes were less frequent in Uyghur population than in Han population. Our population and ethnic-based study demonstrates that the PPARδ +294C allele maybe an independent risk of IS in Chinese Uyghurs especially in the male (OR 1.99, 95%CI:1.06–3.72) and obesity populations (OR 2.36, 95%CI: 1.19–4.67), which were consistent with Tunisian Population. Moreover, total cholesterol, fasting blood glucose, waist-to-hip ratio, hypertension, history of heart diseases, and negative events may increase the risk of IS, with a trend for HDL to be a protective factor for IS in the Uyghur population. However, larger populations are warranted to validate our findings.
Abbreviations:PPARδ (Peroxisome Proliferator-Activated Receptor Delta), IS (Ischemic stroke), BMI (Body Mass Index), WHR (Waist Hip Ratio), FBG (Fasting blood glucose), TC (Total cholesterol), TG (Triglyceride), OR (Odds ratio), CI (Confidence interval)
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- Ischemic stroke functional outcomes are independently associated with C-reactive protein concentrations and cognitive outcomes with triiodothyronine concentrations: a pilot study.Endocrine. 2014; 45: 213-220
- Amelioration of stroke-induced neurological deficiency by lyophilized powder of catapol and puerarin.Int. J. Biol. Sci. 2014; 10: 448-456
- Risk of coronary heart disease and risk of stroke in women with polycystic ovary syndrome: a systematic review and meta-analysis.Int. J. Cardiol. 2014; 176: 486-487
- A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.Proc. Natl. Acad. Sci. U. S. A. 2001; 98: 5306-5311
- Vascular PPARdelta protects against stroke-induced brain injury.Arterioscler. Thromb. Vasc. Biol. 2011; 31: 574-581
- Characterization of the human peroxisome proliferator activated receptor delta gene and its expression.Int. J. Mol. Med. 2000; 6: 73-81
- Association of the cyba, ppargc1a, pparg3, and ppard gene variants with coronary artery disease and metabolic risk factors of coronary atherosclerosis in a Russian population.Heart Vessel. 2010; 25: 229-236
- Effect of genetic polymorphism +294T/C in peroxisome proliferator-activated receptor delta on the risk of ischemic stroke in a Tunisian population.J. Mol. Neurosci. 2013; 50: 360-367
- Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men.J. Intern. Med. 2003; 254: 597-604
- Analysis of genomic admixture in Uyghur and its implication in mapping strategy.Am. J. Hum. Genet. 2008; 82: 883-894
- Association of endothelial nitric oxide synthase gene mini-satellite marker VNTR polymorphism with ischemic stroke in the Chinese Uyghur population.Int. J. Cardiol. 2014; 174: 812-814
- Lack of association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Uyghur population.J. Neurol. Sci. 2012; 323: 52-55
- 3rd. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Toast. Trial of org 10172 in acute stroke treatment.Stroke. 1993; 24: 35-41
- Peroxisome proliferator-activated receptor delta +294T > C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Lipids Health Dis. 2010; 9: 145
- The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls.Atherosclerosis. 2005; 183: 336-341
- Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research tayside study.J. Clin. Endocrinol. Metab. 2010; 95: 1830-1837
- Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta).Mol. Cell. Biol. 2000; 20: 5119-5128
- Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.Proc. Natl. Acad. Sci. U. S. A. 2002; 99: 303-308
- Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism.Circ. Res. 2003; 92: 518-524
- Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis.Arterioscler. Thromb. Vasc. Biol. 2007; 27: 63-69
- Critical roles of the nuclear receptor PPARbeta (peroxisome-proliferator-activated receptor beta) in skin wound healing.Biochem. Soc. Trans. 2004; 32: 97-102
- Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men.Arterioscler. Thromb. Vasc. Biol. 2003; 23: 637-643
- Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha l162v.Int. J. Obes. 2006; 30: 1709-1713
Published online: August 17, 2015
Accepted: August 14, 2015
Received in revised form: August 12, 2015
Received: July 9, 2015
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