Highlights
- •Myelination along the optic nerve as measured by VEP latencies, is reflected in various temporal aspects of visual impairment.
- •Correlations between motion perception and visual temporal resolution abilities were found in optic neuritis affected eyes.
- •Correlations were specific to patients' affected eyes and were not evident for static visual functions.
- •Fellow eyes' VEP latencies were best predicted by the VEP latencies of the affected eyes.
Abstract
The study aims to test whether impaired conduction velocities following optic neuritis
(ON) serve as a limiting factor on various temporal, as compared to static, aspects
of vision. Critical Flicker fusion frequency (CFFF), two motion perception tasks (object
and number-from-motion extraction tasks), high and low contrast acuities, and visual
evoked potentials (VEPs) were assessed in 23 ON patients. Strong correlations were
found between the various dynamic visual function scores. Furthermore, regression
models revealed that each of the dynamic visual functions significantly predicted
VEP latencies. These findings were specific to patients' affected eyes and were not
evident for static visual functions. Fellow eyes' VEP latencies were best predicted
by the VEP latencies of the affected eyes. The similar impact of VEP latencies on
various dynamic visual functions suggests conduction velocity to be the common limiting
factor for temporal-related visual perceptual abilities. The specificity of these
findings to the patients' affected eyes and to dynamic visual functions highlights
the precision of dynamic visual functions for identifying demyelinative attack. Prolonged
VEP latencies in the fellow eyes seem to stem from different patho-physiological processes.
The hypothesis that inter-eye synchronization in conduction latencies is important
to accomplish visual processing (binocular vision) is further discussed.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Seeing slow and seeing fast: two limits on perception.Trends Cogn. Sci. 2009; 13: 216-221
- Visual acuity as measured by dynamic and static tests: a comparative evaluation.J. Appl. Psychol. 1966; 50: 460-466
- Flicker fusion thresholds in multiple sclerosis.AMA Arch. Neurol. Psychiatry. 1957; 77: 134-139
- Impaired temporal resolution of vision after acute retrobulbar neuritis.Brain. 1976; 99: 255-268
- The temporal integration and resolution of velocity signals.Vis. Res. 1991; 31: 907-914
- Demyelination affects temporal aspects of perception: an optic neuritis study.Ann. Neurol. 2012; 71: 531-538
- Flicker fusion in multiple sclerosis.J. Neurol. Neurosurg. Psychiatry. 1961; 24: 260-265
- Critical flicker frequency in acute and recovered optic neuritis.Jpn. J. Ophthalmol. 1993; 37: 122-129
- Impaired critical flicker frequency in recovered optic neuritis.Ann. Neurol. 1991; 30: 213-215
- Various stages of optic neuritis assessed by subjective brightness of flicker.Arch. Ophthalmol. 1989; 107: 63-68
- Recognition of motion-defined shapes in patients with multiple sclerosis and optic neuritis.Brain. 1991; 114: 1129-1155
- Motion perception in optic neuropathy.Neurology. 1994; 44: 273-278
- Sustained motion perception deficit following optic neuritis: behavioral and cortical evidence.Neurology. 2011; 76: 2103-2111
- Dynamic visual tests to identify and quantify visual damage and repair following demyelination in optic neuritis patients.J. Vis. Exp. 2014; 86
- Visual function and pattern visual evoked response in optic neuritis.Br. J. Ophthalmol. 1987; 71: 602-608
- Visual evoked potentials and the visuogram in multiple sclerosis.Ann. Neurol. 1979; 5: 40-47
- Pattern visual evoked potentials and spatial vision in retrobulbar neuritis and multiple sclerosis.Arch. Neurol. 1984; 41: 198-201
- Long-term recovery and fellow eye deterioration after optic neuritis, determined by serial visual evoked potentials.J. Neurol. 1999; 246: 776-782
- Temporal reorganization to overcome monocular demyelination.Neurology. 2013; 81: 702-709
- Perceptual learning of motion leads to faster flicker perception.PLoS One. 2006; 1: e28
- The consequences of optic neuritis: more than meets the eye.Neurology. 2011; 76: 2052-2053
- Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning—an ultrahigh-field MR pilot study.Eur. Radiol. 2015; 25: 122-131
- Central adaptation after optic neuritis: is the whole greater than the sum of its parts?.Neurology. 2013; 81: 698-699
Article info
Publication history
Published online: July 23, 2015
Accepted:
July 22,
2015
Received in revised form:
July 1,
2015
Received:
May 19,
2015
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
