Highlights
- •We evaluated ultrasound and MRI in assessing peripheral nerve pathology in CIDP.
- •Both methods showed the same morphological nerve alterations in correlation to ODSS.
- •Patients with low ODSS and no escalation therapy had normal fascicular structure.
- •Patients with high ODSS and escalating therapy showed isolated enlarged fascicles.
- •Degenerated nerves correlated with high ODSS despite escalating treatment.
Abstract
Introduction
We investigated the applicability of nerve ultrasound and magnetic resonance imaging
(MRI) in chronic inflammatory demyelinating polyneuropathy (CIDP).
Methods
We systematically examined several nerves with ultrasound and the lumbar roots and
tibial nerve in the popliteal fossa of nine CIDP patients with MRI additionally to
the nerve conduction studies.
Results
Patients with overall disability sum score (ODSS) 2–3 were characterised by normal
fascicular structure in MRI and ultrasound. Patients with higher ODSS showed isolated
enlarged fascicles and increased cross sectional area (CSA) of the peripheral nerves
and of the diameter of the cauda equina and L5 root, whereas two of them showed atrophic
fascicles in both imaging techniques.
Conclusions
Nerve ultrasound and MRI findings show the same morphological fascicle alterations
in peripheral nerves in correlation to ODSS. Nerve ultrasound as an affordable tool,
easy and quick to perform, could replace MRI in daily routine for monitoring peripheral
nerve morphology.
Keywords
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Article info
Publication history
Published online: July 22, 2015
Accepted:
July 21,
2015
Received in revised form:
June 26,
2015
Received:
May 13,
2015
Footnotes
☆Funding source: There was no funding source.
☆☆Conflicts of interest: Kalliopi Pitarokoili, Antonios Kerasnoudis and Marc Schlamann report no disclosures. R. Gold has received consultation fees and speakers honoraria from BayerSchering, BiogenIdec, MerckSerono, Novartis, Sanofi-Aventis and TEVA. He also acknowledges grant support from Bayer Schering, Biogen Idec, Merck Serono, Sanofi-Aventis and TEVA all not related to this manuscript. Min-Suk Yoon has received speaker's honoraria from CSL Behring, all not related to this manuscript.
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
