Highlights
- •The purpose was to clarify difference between PSP and PD in the dynamic CSF flow.
- •CSF flow was calculated by 15 images in MRI that was taken through a cardiac cycle.
- •The width of the CSF velocity showed significant declines in PSP than PD patients.
- •MRI measurement showed a good discrimination on the area of the midbrain aqueduct.
Abstract
Objective
The purpose of this study was to clarify the difference between PSP and PD from the
viewpoint of dynamic cerebrospinal fluid (CSF) flow focusing on the midbrain aqueduct.
Methods
Thirty-three PD patients (mean age 69.2 ± 7.9) and 35 PSP patients (mean age 70.5 ± 6.6) were included in this study. CSF flow was calculated by 15 images in an equidistant
magnetic resonance imaging (MRI) sequence that was taken throughout a cardiac cycle.
Results
Absolute values of the velocity (time points of 2–6 and 12–15, *p < 0.05), and the width of the CSF velocity (Vheight) (PSP, 5.1 ± 2.3 cm/s; PD, 6.0 ± 1.6 cm/s, p < 0.05) effectively discriminated PSP from PD patients. On the other hand, conventional
MRI measurements discriminated well the midbrain aqueduct area (Area) (PSP, 7.7 ± 2.6 mm2; PD, 5.4 ± 1.8 mm2, p < 0.01). Two cutoff value lines (Vheight: 4.75, Area: 5.77) of the ROC curve analysis
established two areas for discriminating PSP from PD.
Conclusion
In the present dynamic CSF flow study, it was newly found that mean velocity of each
time point and Vheight showed a more significant decline in PSP than in PD patients,
providing a sensitive biomarker for differentiating them. The combination of Vheight
and Area could further discriminate PSP from PD patients.
Keywords
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Article info
Publication history
Published online: July 21, 2015
Accepted:
July 16,
2015
Received in revised form:
June 25,
2015
Received:
January 7,
2015
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
