Highlights
- •BCPI is an extremely rare neurological disorder.
- •It is related to vertebrobasilar artery stenosis with a pathogenesis of hypoperfusion.
- •Its prognosis was poor.
- •The sign of BCPI on DWI was termed Mickey Mouse ears.
- •The pons is the other most common location of infarction beside BCP.
Abstract
Background
Bilateral cerebral peduncular infarction (BCPI) is an extremely rare neurological
disorder, and related literature is scarce. This study investigated the clinical manifestations,
magnetic resonance imaging (MRI) features and prognosis of BCPI.
Method
We retrospectively reviewed the clinical features, MRI and magnetic resonance angiography
manifestations, and prognosis of 14 patients with BCPI, confirmed by diffusion-weighted
MRI from 5050 cerebral infarction patients at our medical center from January 2007
to June 2013.
Result
Eleven of the 14 (78.6%) patients had quadriplegia and 9 (64.3%) had decreased consciousness.
At the most severe stage, the National Institutes of Health Stroke Scale scores ranged
from grades 4 to 26 (mean grade, 18.9). Eleven (78.6%) cases were caused by large
artery atherosclerosis. Besides the bilateral cerebral peduncle, the pons (85.7%)
and cerebellum (42.9%) were the other infarct locations. Twelve (85.7%) patients had
vertebrobasilar artery occlusion or severe stenosis, and 12 (85.7%) did not have collateral
patency of the posterior cerebral artery. Thirteen (92.9%) patients had poor prognosis
and 9 of them died.
Occlusion
BCPI is a very rare disorder and associated with severe vertebrobasilar artery stenosis
or occlusion without collateral patency of the posterior communicating artery. It
has a very poor prognosis.
Keywords
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Article info
Publication history
Published online: July 14, 2015
Accepted:
July 13,
2015
Received in revised form:
June 17,
2015
Received:
March 13,
2015
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
