- •Ab response against EBNA1, MAP106c, MBP and HERV-Wenv was evaluated in MS patients.
- •No difference was observed during natalizumab treatment for EBNA1, MAP106c, and MBP.
- •Difference in the Ab response was observed for HERV-Wenv during natalizumab exposure.
- •Natalizumab treatment reduces Ab production against HERV-Wenv in MS patients.
Multiple Sclerosis (MS) is a heterogeneous disorder of the central nervous system (CNS) that begins as an inflammatory autoimmune disorder mediated by auto-reactive lymphocyte followed by microglial activation and chronic degeneration. The etiology of Multiple Sclerosis (MS) is unknown but several data support the hypothesis of possible infectious agents which may act as a trigger for the pathogenic cascade. Human endogenous retrovirus (HERV-W/MSRV), Epstein Barr Virus (EBV) and Mycobacterium avium ss. paratuberculosis (MAP) have been associated to Multiple Sclerosis. In this study, we evaluated the humoral response against different peptides: the human endogenous retrovirus HERV-Wenv73–88, MAP106c121–132 from MAP, EBNA1 400–413 from EBV and the homologous human peptide MBP85–98 in a cohort of MS patients treated with natalizumab. Results showed a statistically significant difference in the response against the HERV-W peptide in MS patients after two years of natalizumab treatment.
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Published online: July 08, 2015
Accepted: July 6, 2015
Received in revised form: July 3, 2015
Received: April 10, 2015
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.