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Letter to the Editor| Volume 352, ISSUE 1-2, P129-131, May 15, 2015

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Metronidazole-induced encephalopathy with contrast enhancing lesions on MRI

Published:March 30, 2015DOI:https://doi.org/10.1016/j.jns.2015.03.039
      Subacute progressive encephalopathy is a rare complication of metronidazole treatment [
      • Bonkowsky J.L.
      • Sondrup C.
      • Benedict S.L.
      Acute reversible cerebellar lesions associated with metronidazole therapy.
      ,
      • Woodruff B.K.
      • Wijdicks E.F.
      • Marshall W.F.
      Reversible metronidazole-induced lesions of the cerebellar dentate nuclei.
      ]. Previous reports have shown characteristic findings on brain magnetic resonance imaging (MRI), but detailed serial findings have rarely been described. We herein report a patient with metronidazole-induced encephalopathy who initially showed gadolinium-enhanced lesions in the corpus callosum, typical for the disorder. However, follow-up MRI revealed prominent cystic changes in the bilateral white matter and corpus callosum.

      Keywords

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