Letter to the Editor| Volume 352, ISSUE 1-2, P125-126, May 15, 2015

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Acute ischemic strokes from small vessel vasculitis due to disseminated histoplasmosis infection

Published:March 30, 2015DOI:


      • Disseminated histoplasmosis with CNS involvement is not only seen in immunocompromised patients
      • The diagnosis of primary CNS vasculitis should only be made after more common causes of vessel inflammation are excluded
      • Vasculitis should be considered in patients with multi vessel distribution infarcts in the setting of systemic infection
      • Disseminated histoplasmosis can cause a small vessel cerebral vasculitis in the absence of clinically apparent meningitis


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        • Trofa D.
        • Nosanchuk J.
        Histoplasmosis of the central nervous system.
        J Neuroparasitol. Aug 2012; 3: 1-7
        • Zalduondo F.M.
        • Provenzale J.M.
        • Hulette C.
        • Gorecki J.P.
        Meningitis, vasculitis, and cerebritis caused by CNS histoplasmosis: radiologic–pathologic correlation.
        AJR. 1996; 166: 194-196
        • Wheat J.
        • Sarosi G.
        • McKinsey D.
        • Hamill R.
        • Bradsher R.
        • Johnson P.
        • et al.
        Practice guidelines for the management of patients with histoplasmosis.
        Clin Infect Dis. 2000; 30: 688-695
        • Ramireddy S.
        • Wanger A.
        • Ostrosky L.
        An instructive case of CNS histoplasmosis in an immunocompetent host.
        Med Mycol Case Rep. 2012; 1: 69-71
        • Nguyen F.N.
        • Kar J.K.
        • Zakaria A.
        • Schiess M.
        Isolated central nervous system histoplasmosis presenting with ischemic pontine stroke and meningitis in an immune-competent patient.
        JAMA Neurol. 2013; 70: 638-641
        • Stone J.H.
        • Pomper M.G.
        • Hellman D.B.
        Histoplasmosis mimicking vasculitis of the central nervous system.
        J Rheumatol. 1998; 25: 1644-1648