Research Article| Volume 352, ISSUE 1-2, P68-73, May 15, 2015

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Serum levels of procalcitonin and high sensitivity C-reactive protein are associated with long-term mortality in acute ischemic stroke

Published:March 26, 2015DOI:


      • PCT and Hs-CRP were associated with ischemic stroke severity.
      • Non-survivors had significantly increased PCT and Hs-CRP levels on admission.
      • Multivariate COX regression analysis showed that PCT and Hs-CRP were independent mortality predictors.
      • The prognostic accuracy of PCT was higher compared to Hs-CRP, NIHSS score and other markers.



      The aim of this study is to assess the prognostic value of systemic inflammation, as measured by the inflammatory biomarkers PCT and Hs-CRP, to predict the long-term mortality in ischemic stroke patients.


      We prospectively studied 374 patients with ischemic stroke who were admitted within 24 h after the onset of symptoms. Serum levels of PCT, Hs-CRP and NIH stroke scale (NIHSS) were measured at the time of admission. Clinical follow-up was performed at 1 year. The prognostic value of PCT to predict the mortality within one year was compared with Hs-CRP, NIHSS and with other known outcome predictors.


      In the 64 non-survival patients, serum PCT levels were significantly (P < 0.0001) higher compared with those in survival patients. Multivariate COX regression analysis showed that log-transformed PCT and Hs-CRP were independent mortality predictors with adjusted hazard ratio of 4.24 (95% confidence interval [CI], 2.42–6.30) and 15.37 (95% confidence interval [CI], 3.25–41.08). The area under the receiver operating characteristic curve of PCT and Hs-CRP were 0.89 (95% CI, 0.85–0.93) and 0.68 (95% CI, 0.59–0.77) for mortality, respectively.


      Serum levels of PCT and HS-CRP at admission were independent predictor of long-term mortality after ischemic stroke in a Chinese sample.


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