Highlights
- •PCT and Hs-CRP were associated with ischemic stroke severity.
- •Non-survivors had significantly increased PCT and Hs-CRP levels on admission.
- •Multivariate COX regression analysis showed that PCT and Hs-CRP were independent mortality predictors.
- •The prognostic accuracy of PCT was higher compared to Hs-CRP, NIHSS score and other markers.
Abstract
Objective
The aim of this study is to assess the prognostic value of systemic inflammation,
as measured by the inflammatory biomarkers PCT and Hs-CRP, to predict the long-term
mortality in ischemic stroke patients.
Methods
We prospectively studied 374 patients with ischemic stroke who were admitted within
24 h after the onset of symptoms. Serum levels of PCT, Hs-CRP and NIH stroke scale (NIHSS)
were measured at the time of admission. Clinical follow-up was performed at 1 year. The prognostic value of PCT to predict the mortality within one year was compared
with Hs-CRP, NIHSS and with other known outcome predictors.
Results
In the 64 non-survival patients, serum PCT levels were significantly (P < 0.0001) higher compared with those in survival patients. Multivariate COX regression
analysis showed that log-transformed PCT and Hs-CRP were independent mortality predictors
with adjusted hazard ratio of 4.24 (95% confidence interval [CI], 2.42–6.30) and 15.37
(95% confidence interval [CI], 3.25–41.08). The area under the receiver operating
characteristic curve of PCT and Hs-CRP were 0.89 (95% CI, 0.85–0.93) and 0.68 (95%
CI, 0.59–0.77) for mortality, respectively.
Conclusion
Serum levels of PCT and HS-CRP at admission were independent predictor of long-term
mortality after ischemic stroke in a Chinese sample.
Keywords
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Article info
Publication history
Published online: March 26, 2015
Accepted:
March 18,
2015
Received in revised form:
March 17,
2015
Received:
December 10,
2014
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
