Abstract
Stroke is the second main cause of morbidity and mortality worldwide. The rationale
for the use of mesenchymal stem cells (MSCs) in stroke is based on the capacity of
MSCs to secrete a large variety of bioactive molecules such as growth factors, cytokines
and chemokines leading to reduction of inflammation, increased neurogenesis from the
germinative niches of central nervous system, increased angiogenesis, effects on astrocytes,
oligodendrocytes and axons. This review presents the data derived from experimental
studies and the evidence available from clinical trials about the use of MSCs in stroke
therapy.
Keywords
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Article info
Publication history
Published online: March 18, 2015
Accepted:
March 10,
2015
Received in revised form:
March 9,
2015
Received:
December 18,
2014
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
