Abstract
Background & objectives
The role of human leukocyte antigen (HLA) in clinical response to immunotherapy is
not completely known. In this study we evaluated the relationship between HLA-DRB1
genotype, which has been proved to be more common in Iranian MS patients, and clinical
response to interferon-beta (IFNβ), which is the most common immunotherapy for relapsing–remitting
MS.
Design and setting
In this study 68 Iranian patients with confirmed diagnosis of RRMS who had been referred
to and admitted in Neurology Department of Amiralam and Khatam Hospitals in Tehran
were selected. Patients were followed prospectively for 2 years since initiation of therapy and clinical data, including EDSS scores were recorded
every 3 months. MRI was performed at the time of diagnosis and each year.
Methods
HLA-DRB1 typing was performed by polymerase chain reaction (PCR) for all patients
and data was analyzed by STATA 12th edition.
Results
There were 47 (69.1%) responders and 21 (30.9%) non-responders. These two groups were
demographically and clinically comparable. Fisher's exact test did not show any difference
between HLA-DRB1 allele frequencies in responders and non-responders.
Conclusions
Our findings confirmed the lack of association between HLA-DRB1 and clinical response
to IFNβ among MS patients as previous studies had done.
Keywords
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Article info
Publication history
Published online: March 10, 2015
Accepted:
March 2,
2015
Received in revised form:
February 9,
2015
Received:
October 4,
2014
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
