Highlights
- •The alternation of DNA methylation in PD-related genes and methylation associated factors changes.
- •Histone modifications occurred in PD.
- •Changes of non-coding RNAs found in PD.
- •Epigenetic-based diagnosis and therapeutic strategies for PD patients.
Abstract
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease,
but its pathogenesis is not fully understood. The selective neuronal cell death in
PD has been considered to result from a complex interaction between genetic and environmental
factors, but the nature of the relationship between the two chief modifiers remains
to be elucidated. There is a growing body of evidence supporting the role of epigenetics
in the development and progression of many neurodegenerative diseases including PD.
Epigenetic modification refers to changes in gene expression or function without changes
in DNA sequence, which mainly includes DNA methylation, post-modifications of histone,
and non-coding RNAs. In this review, we will focus on the abnormal epigenetic modifications
involved in the pathogenesis of PD and their implications for the development of future
diagnostic and therapeutic strategies.
Keywords
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Article info
Publication history
Published online: December 18, 2014
Accepted:
December 10,
2014
Received in revised form:
December 1,
2014
Received:
July 15,
2014
Identification
Copyright
© 2014 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
