Abstract
Background
Month of birth has been associated in some studies with the susceptibility to develop
Multiple Sclerosis (MS). However, only few studies have evaluated whether birth timing
also affects disease progression.
Objectives
To assess whether season and month of birth are associated with disease progression
in a large cohort of Italian patients.
Methods
Quantile regression was used to analyze the impact of each month and season of birth
with all the others combined on the median Multiple Sclerosis Severity Score of 1866
MS patients.
Results
No significant temporal trend was found after adjustment for multiple comparisons.
Conclusions
Birth timing showed no association with MS progression in Italian patients.
Keywords
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Article info
Publication history
Published online: August 22, 2014
Accepted:
August 16,
2014
Received in revised form:
July 30,
2014
Received:
June 10,
2014
Identification
Copyright
© 2014 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
