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Multiple sclerosis progression is not associated with birth timing in Italy

  • Ausiliatrice Lucenti
    Correspondence
    Corresponding author at: Department of Health Sciences, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. Tel.: +39 02 6448 8162; fax: +39 02 6448 8262.
    Affiliations
    MS Centre, SCDU Neurology, Head and Neck Department, AOU “Maggiore della Carità”, Corso Mazzini 18, 28100 Novara, Italy

    Department of Health Sciences, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy
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  • Stefania Galimberti
    Affiliations
    Department of Health Sciences, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy
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  • Nadia Barizzone
    Affiliations
    Department of Health Sciences, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy

    Interdisciplinary Research Center of Autoimmune Diseases IRCAD, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
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  • Paola Naldi
    Affiliations
    MS Centre, SCDU Neurology, Head and Neck Department, AOU “Maggiore della Carità”, Corso Mazzini 18, 28100 Novara, Italy
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  • PROGEMUS Group
    Author Footnotes
    1 Membership of the PROGEMUS Group and the PROGRESSO Group is provided in the Acknowledgments.
  • PROGRESSO Group
    Author Footnotes
    1 Membership of the PROGEMUS Group and the PROGRESSO Group is provided in the Acknowledgments.
  • Giancarlo Comi
    Affiliations
    Scientific Institute University Vita-Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
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  • Filippo Martinelli Boneschi
    Affiliations
    Department of Neurology & Laboratory of Neurogenetics of Complex Disease, CNS Inflammatory Unit, Institute of Experimental Neurology, Scientific Institute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
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  • Sandra D'Alfonso
    Affiliations
    Department of Health Sciences, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy

    Interdisciplinary Research Center of Autoimmune Diseases IRCAD, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
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  • Maurizio A. Leone
    Affiliations
    MS Centre, SCDU Neurology, Head and Neck Department, AOU “Maggiore della Carità”, Corso Mazzini 18, 28100 Novara, Italy

    Interdisciplinary Research Center of Autoimmune Diseases IRCAD, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
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  • Author Footnotes
    1 Membership of the PROGEMUS Group and the PROGRESSO Group is provided in the Acknowledgments.
Published:August 22, 2014DOI:https://doi.org/10.1016/j.jns.2014.08.021

      Abstract

      Background

      Month of birth has been associated in some studies with the susceptibility to develop Multiple Sclerosis (MS). However, only few studies have evaluated whether birth timing also affects disease progression.

      Objectives

      To assess whether season and month of birth are associated with disease progression in a large cohort of Italian patients.

      Methods

      Quantile regression was used to analyze the impact of each month and season of birth with all the others combined on the median Multiple Sclerosis Severity Score of 1866 MS patients.

      Results

      No significant temporal trend was found after adjustment for multiple comparisons.

      Conclusions

      Birth timing showed no association with MS progression in Italian patients.

      Keywords

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