Highlights
- •Evaluation of differences in natural killer receptor expression in MS patients
- •Newly diagnosedpatients havea higher NCR1 expression level than other groups.
- •Pharmacologically treated MS patients show a modulated NK cell expression.
Abstract
Natural killer (NK) cells are implicated in many autoimmune diseases but their role
in multiple sclerosis (MS) remains still unknown. This study was aimed to evaluate
the expression levels of a NK cell receptor (NCR1) in patients with diagnosis of MS.
Particularly, the study took into account patients undergoing pharmacological therapy
with interferon-beta or natalizumab and patients never treated since first-time diagnosed
for MS.
Expression levels of NCR1 receptor were evaluated in protein extracts of peripheral
blood mononuclear cells performing western blot analysis.
Our results show that MS patients display higher NCR1 expression levels than healthy
controls. Moreover, patients with a first diagnosis of MS display the highest level
of NCR1 when compared with patients pharmacologically treated with interferon-beta
or natalizumab.
Therefore, pharmacologically treated MS patients show a modulated NK cell expression.
Keywords
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References
- Incidence and prevalence of multiple sclerosis in Europe: a systematic review.BMC Neurol. 2013; 13: 128
- Geographical variations in sex ratio trends over time in multiple sclerosis.PLoS One. 2012; 7: e48078
- Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS).Br J Pharmacol. 2011; 164: 1079-1106
- The role of natural killer cells in multiple sclerosis and their therapeutic implications.Front Immunol. 2013; 4: 63
- Dendritic cells in multiple sclerosis: key players in the immunopathogenesis, key players for new cellular immunotherapies?.Mult Scler. 2013; 19: 995-1002
- Natural killer cells and their receptors in multiple sclerosis.Brain. 2013; 136: 2657-2676
- Natural killer cells in human autoimmune disorders.Arthritis Res Ther. 2013; 15: 216
- Innate immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1).J Neuroinflammation. 2012; 9: 1
- Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells.Nature. 2001; 409: 1055-1060
Article info
Publication history
Published online: July 29, 2014
Accepted:
July 21,
2014
Received in revised form:
July 4,
2014
Received:
April 22,
2014
Identification
Copyright
© 2014 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
