Highlights
- •This is the first report about ICAM1 gene polymorphisms and migraine.
- •The E/E genotype of the K469E polymorphism is an important risk factor for migraine.
- •This polymorphism affects ICAM1 serum levels.
- •Opening up the potential development of ICAM1 K469E E allele-specific therapeutics
Abstract
Objective
To investigate the associations of a polymorphism in the intercellular adhesion molecule-1
(ICAM1) gene, and ICAM1 serum levels, with migraine and migraine subtypes in a Han Chinese
population.
Method
We used PCR-restriction fragment length polymorphism (PCR–RFLP) and gene sequencing
to analyze the genotype and allelic frequencies of the K469E (rs5498) and G241R (rs1799969) ICAM1 polymorphisms between migraine cases and controls. Serum levels of ICAM1 were tested
by enzyme linked immunosorbent assay (ELISA).
Results
(1) We found significant higher frequencies of the distribution of the E/E genotype
and the E allele of the K469E polymorphism between migraine cases and controls (χ2 = 4.948 & P < 0.05 and χ2 = 13.990 & P < 0.01, respectively), and between a migraine without aura subtype of migraine cases
and controls (χ2 = 5.265 & P < 0.05; χ2 = 20.501 & P < 0.01, respectively). After correction by conditional logistical regression, the frequency
distribution difference of the E/E genotype between the migraine cases and controls
remained statistically significant (OR = 32.85, 95% CI:4.22–28.79, P = 0.007.) (2) ICAM1 serum levels were significantly higher in migraine cases than in
controls (P < 0.01) and, within migraine cases, were significantly higher in K469E E allele carriers
than in K allele carriers (P < 0.01).
Conclusions
Our data indicate that the E/E genotype of the ICAM1 K469E polymorphism may be an important risk factor for migraine in a Han Chinese
population, and that this polymorphism affects ICAM1 serum levels. Although the independent
risk factor constituted by this polymorphism in other ethnic groups requires further
study, our studies raise the possibility of the development of ICAM1 K469E E allele-specific therapeutics for the prevention and treatment of migraine
in the Chinese Han population.
Keywords
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Article info
Publication history
Published online: July 17, 2014
Accepted:
July 12,
2014
Received in revised form:
July 9,
2014
Received:
June 10,
2014
Identification
Copyright
© 2014 Published by Elsevier Inc.
