Numb chin syndrome (NCS) refers to abnormal sensation in the chin and lower lip within the mental nerve distribution. NCS is caused by malignant infiltration of the inferior alveolar nerve or the mental nerve and its branches, or through compression of these nerves by jaw metastases or local tumors [
]. This syndrome sometimes presents as the first symptom of metastasis, and therefore requires prompt and accurate diagnosis. However, its diagnosis can be difficult due to the low sensitivity of imaging studies such as computed tomography (CT), panoramic radiography of the jaw or bone scan [
- Laurencet F.M.
- Anchisi S.
- Tullen E.
- Dietrich P.Y.
Mental neuropathy: report of five cases and review of the literature.
Crit Rev Oncol Hematol. 2000; 34: 71-79
- Friedrich R.E.
Mental neuropathy (numb chin syndrome) leading to diagnosis of metastatic mediastinal cancer.
Anticancer Res. 2010; 30: 1819-1821
- Fan Y.
- Luka R.
- Noronha A.
Non-Hodgkin lymphoma presenting with numb chin syndrome.
BMJ Case Rep. 2011; https://doi.org/10.1136/bcr.01.2011.3712
- Seymour J.F.
- Rodriguez M.A.
Mental neuropathy (numb chin syndrome): a harbinger of tumor progression or relapse.
Cancer. 1993; 71: 874-875
5]. In addition, routine brain magnetic resonance imaging (MRI) may give false negative results in skull base and maxillo-mandibular lesions.
- Baskaran R.K.
- Smith M.
Numb chin syndrome—a reflection of systemic malignancy.
World J Surg Oncol. 2006; 4: 52
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- Mental neuropathy: report of five cases and review of the literature.Crit Rev Oncol Hematol. 2000; 34: 71-79
- Mental neuropathy (numb chin syndrome) leading to diagnosis of metastatic mediastinal cancer.Anticancer Res. 2010; 30: 1819-1821
- Non-Hodgkin lymphoma presenting with numb chin syndrome.BMJ Case Rep. 2011; https://doi.org/10.1136/bcr.01.2011.3712
- Mental neuropathy (numb chin syndrome): a harbinger of tumor progression or relapse.Cancer. 1993; 71: 874-875
- Numb chin syndrome—a reflection of systemic malignancy.World J Surg Oncol. 2006; 4: 52
- Unusual presentation of ‘numb chin syndrome’ as the manifestation of metastatic adenocarcinoma of the lung.Int J Surg Case Rep. 2013; 4: 1097-1099
- Numb chin syndrome in acute myeloid leukemia.Am J Med Sci. 2012; 344: 237-240
- Bilateral numb chin syndrome leading to a diagnosis of Burkitt's cell acute lymphocytic leukemia: a case report and literature review.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011; 111: e11-e16
- Numb chin syndrome: a rare and often overlooked symptom.J Oral Facial Pain Headache. 2014; 28: 80-90
Published online: July 17, 2014
Accepted: July 10, 2014
Received in revised form: June 9, 2014
Received: May 6, 2014
© 2014 Elsevier B.V. Published by Elsevier Inc. All rights reserved.