Uhthoff's phenomenon (UP) is a stereotyped, brief disturbance in neurological functioning
triggered by any increase in core body temperature (CBT) [
[1]
]. It is related to recurrent fluctuations in neuronal conduction of demyelinated axons,
being a feature of multiple sclerosis (MS) [
[1]
]. Radiologically isolated syndrome (RIS) has been defined by Okuda [
[2]
] as an incidental MRI finding of central nervous system (CNS) white matter anomalies
suggestive of MS (according to Barkhof's criteria for dissemination in space), with
no historical accounts of remitting neurological symptoms, no related-disability and
no other better explanation (e.g. substance abuse, medical condition, cerebrovascular
disease). We describe a case with transient and recurrent oscillopsia, interpreted
as UP, with MRI suggesting demyelinating lesions.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Uhthoff's phenomena in MS—clinical features and pathophysiology.Nat Rev Neurol. 2013 Sep; 9: 535-540
- Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome. Neurology 2009; 72: 800–805. Erratum.Neurology. 2009; 73: 1714
- MRI and the diagnosis of multiple sclerosis: expanding the concept of “no better explanation”.Lancet Neurol. 2006; 5: 841-852
- The neurology of eye movements.3rd ed. Oxford University Press, 1999: 410 ([479–482])
- Clinical phenotype and mutations in connexin 26 (DFNB1/GJB2), the most common cause of childhood hearing loss.Am J Med Genet. 1999; 89: 130-136
- Vestibular dysfunction in DFNB1 deafness.Am J Med Genet A. 2011 May; 155: 993-1000
- Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria.Ann Neurol. 2011 February; 69: 292-302
- Radiologically isolated syndrome: incidental magnetic resonance imaging findings suggestive of multiple sclerosis, a systematic review.Mult Scler. 2013; 19: 271-280
- Radiologically Isolated Syndrome Consortium (RISC); Club Francophone de la Sclérose en Plaques (CFSEP). Radiologically isolated syndrome: 5-year risk for an initial clinical event.PLoS One. Mar 5 2014; 9: e90509
- Prevalence of radiologically isolated syndrome and white matter signal abnormalities in healthy relatives of multiple sclerosis patients.AJNR Am J Neuroradiol. Jul 25 2013; https://doi.org/10.3174/ajnr.A3653
Article info
Publication history
Published online: July 15, 2014
Accepted:
July 8,
2014
Received in revised form:
July 5,
2014
Received:
April 10,
2014
Identification
Copyright
© 2014 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
