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Letter to the Editor| Volume 345, ISSUE 1-2, P260-261, October 15, 2014

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Bilateral cytotoxic edema of the centrum semiovale in uremic encephalopathy

      Uremic encephalopathy (UE) is a relatively new entity, resulting from a variety of metabolic alterations associated with acute or chronic renal failure. It has a heterogeneous presentation, most often an acute or subacute onset of neurological symptoms including headaches, seizures, confusion, asterixis, ataxia or motor dysfunction [
      • Rizzo M.A
      • Frediani F.
      • Granata A.
      • Ravasi B.
      • Cusi D.
      • Gallieni M.
      Neurological complications of hemodialysis: state of the art.
      ]. Magnetic Resonance Imaging (MRI) findings and clinical presentation have led to the description of two variants of UE: a cortical type, closely related to posterior reversible encephalopathy syndrome (PRES), and a basal ganglia (BG) type, occurring most often in diabetics [
      • Rizzo M.A
      • Frediani F.
      • Granata A.
      • Ravasi B.
      • Cusi D.
      • Gallieni M.
      Neurological complications of hemodialysis: state of the art.
      ,
      • Kang E.
      • Jeon S.J.
      • Choi S.S.
      Uremic encephalopathy with atypical magnetic resonance features on diffusion-weighted images.
      ]. MRI changes consist of reversible vasogenic edema. We present the case of a patient with UE and isolated involvement of the centrum semiovale, an extremely rare presentation. Only two other similar cases are reported in the literature [
      • Kang E.
      • Jeon S.J.
      • Choi S.S.
      Uremic encephalopathy with atypical magnetic resonance features on diffusion-weighted images.
      ,
      • Prüss H.
      • Siebert E.
      • Masuhr F.
      Reversible cytotoxic brain edema and facial weakness in uremic encephalopathy.
      ], with identical imaging findings, suggestive of a new type of UE.
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