Highlights
- •The MAO gene may play important roles in the development of PD.
- •The relationships between MAO polymorphisms as a modifier of PD susceptibility
- •The first on the association of MAO genetic polymorphisms with susceptibility to PD
Abstract
Objective
We carried out a meta-analysis focusing on the relationships between rs1137070 C>T
and rs1799836 A>G polymorphisms in the MAO gene as a modifier of Parkinson disease (PD) susceptibility.
Method
A literature search of the Cochrane Library Database, Web of Science, PubMed, CINAHL,
EMBASE, and the Chinese Biomedical Database (CBM) was performed without any language
restrictions on articles published before April 10st, 2014. We choose the STATA 12.0
statistical software to deal with statistical data. Crude odds ratios (ORs) estimates
with 95% confidence interval (95% CI) were also provided.
Results
Fourteen independent case–control studies met our predetermined inclusion criteria
and were included in the meta-analysis. Two major polymorphisms rs1137070 C>T and
rs1799836 A>G in the MAO gene were performed in this meta-analysis. When all the eligible studies were pooled
into the meta-analysis, our results indicated that rs1137070 C>T polymorphism and
rs1799836 A>G polymorphism have statistically significant correlation with the increased
risk of PD in the majority groups. Ethnicity-stratified analysis revealed a relation
between the rs1137070 C>T polymorphism and PD risk among Asians and Caucasians in
the majority groups. Additionally, there was an apparent association between the rs1799836
A>G variant and PD risk among the Asian populations under 4 genetic models (G allele
vs. A allele: OR = 0.84, 95% CI = 0.72–0.97, P = 0.021; GG vs. AA + AG: OR = 1.73, 95% CI = 1.25–2.39, P = 0.001; GG vs. AA: OR = 1.56, 95% CI = 1.18–2.04, P = 0.002; GG vs. AG: OR = 3.42, 95% CI = 1.86–6.30, P < 0.001; respectively).
Conclusion
The relationships in the polymorphisms of rs1137070 C>T and rs1799836 A>G in the MAO gene with PD susceptibility observed in our meta-analyses support the view that the
MAO gene may play an important role in the development of PD.
Keywords
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Article info
Publication history
Published online: July 14, 2014
Accepted:
July 7,
2014
Received in revised form:
June 9,
2014
Received:
May 12,
2014
Identification
Copyright
© 2014 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
