Interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine with pleiotropic effects
on the immune response in a number of immune-mediated diseases such as of multiple
sclerosis (MS). As a significant player in the neuro-inflammatory cascade of MS, IL-1β
is produced by monocytes, microglial cells, astrocytes, and cerebral endothelial cells
and facilitates transendothelial migration of activated leukocytes into the CNS environment.
The details of the IL-1β and its specific genotype in the pathogenesis of MS have
been the subject of many scientific studies.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the Neurological SciencesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The analysis of correlation between IL−1B gene expression and genotyping in multiple sclerosis patients.J Neurol Sci. 2014;
- Sharp increase in the incidence and prevalence of multiple sclerosis in Isfahan, Iran.Mult Scler. 2011; 17: 1022-1027
- Increasing female preponderance of multiple sclerosis in Isfahan.Iran: a population−based study, Mult Scler. 2010; 16: 359-361
- Multiple sclerosis in Sistan and Baloochestan.South East Iran, Clin Neurol Neurosurg. 2013; 115: 847-848
- Interleukin−1beta promotes repair of the CNS.J Neurosci. 2001; 21: 7046-7052
Article info
Publication history
Published online: May 14, 2014
Accepted:
May 7,
2014
Received:
May 6,
2014
Identification
Copyright
© 2014 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
