IL1-β expression in multiple sclerosis

      Interleukin-1β (IL-1β) is a potent pro-inflammatory cytokine with pleiotropic effects on the immune response in a number of immune-mediated diseases such as of multiple sclerosis (MS). As a significant player in the neuro-inflammatory cascade of MS, IL-1β is produced by monocytes, microglial cells, astrocytes, and cerebral endothelial cells and facilitates transendothelial migration of activated leukocytes into the CNS environment. The details of the IL-1β and its specific genotype in the pathogenesis of MS have been the subject of many scientific studies.
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