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Ehlers–Danlos Syndrome and Postural Tachycardia Syndrome: A relationship study

Published:March 31, 2014DOI:https://doi.org/10.1016/j.jns.2014.03.002

      Highlights

      • We compare the prevalence of EDS within POTS patients.
      • The prevalence of EDS amongst patients with POTS is statistically significant.
      • We suspect that EDS may be a predictor of POTS.

      Abstract

      Objective

      This study examines a possible relationship between Ehlers–Danlos Syndrome (EDS) and Postural Tachycardia Syndrome (POTS).

      Design/methods

      We retrospectively reviewed 109 medical records of patients suffering from autonomic dysfunction exhibiting at least one POTS symptom from one urban clinic for EDS and POTS diagnoses between 2006 and 2013. The presence of EDS within the POTS and non-POTS populations was calculated and compared to that of the general population.

      Results

      The review revealed 39 (36F:3M) patients with POTS (mean ± SD age, 32.5 ± 11.8 years) with 7 cases of EDS yielding a prevalence of 18% (95% exact CI: 8%, 34%), a statistically significant difference from the suggested prevalence of EDS in the general population of 0.02% (p < 0.0001). 70 patients (53F:17M) without POTS (mean ± SD age, 51.1 ± 14.7 years) contained 3 cases of EDS, yielding a prevalence of 4% (95% exact CI: 1%, 12%), a statistically significant difference from the general population (p < 0.0001). The prevalence of EDS was significantly higher in the POTS group compared to the non-POTS group (p = 0.0329). The odds ratio comparing the odds of EDS for POTS versus non-POTS patients is 4.9 (95% CI: 1.2, 20.1).

      Conclusion

      The presence of EDS may be significantly higher in patients with POTS than that of the general population and in autonomic patients without POTS. We suspect an additional underlying mechanism of POTS caused by EDS.

      Keywords

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