Highlights
- •We compare the prevalence of EDS within POTS patients.
- •The prevalence of EDS amongst patients with POTS is statistically significant.
- •We suspect that EDS may be a predictor of POTS.
Abstract
Objective
This study examines a possible relationship between Ehlers–Danlos Syndrome (EDS) and
Postural Tachycardia Syndrome (POTS).
Design/methods
We retrospectively reviewed 109 medical records of patients suffering from autonomic
dysfunction exhibiting at least one POTS symptom from one urban clinic for EDS and
POTS diagnoses between 2006 and 2013. The presence of EDS within the POTS and non-POTS
populations was calculated and compared to that of the general population.
Results
The review revealed 39 (36F:3M) patients with POTS (mean ± SD age, 32.5 ± 11.8 years) with 7 cases of EDS yielding a prevalence of 18% (95% exact CI: 8%, 34%), a
statistically significant difference from the suggested prevalence of EDS in the general
population of 0.02% (p < 0.0001). 70 patients (53F:17M) without POTS (mean ± SD age, 51.1 ± 14.7 years) contained 3 cases of EDS, yielding a prevalence of 4% (95% exact CI: 1%, 12%),
a statistically significant difference from the general population (p < 0.0001). The prevalence of EDS was significantly higher in the POTS group compared
to the non-POTS group (p = 0.0329). The odds ratio comparing the odds of EDS for POTS versus non-POTS patients
is 4.9 (95% CI: 1.2, 20.1).
Conclusion
The presence of EDS may be significantly higher in patients with POTS than that of
the general population and in autonomic patients without POTS. We suspect an additional
underlying mechanism of POTS caused by EDS.
Keywords
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Article info
Publication history
Published online: March 31, 2014
Accepted:
March 2,
2014
Received in revised form:
February 5,
2014
Received:
November 16,
2013
Identification
Copyright
© 2014 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
