Advertisement
Research Article| Volume 334, ISSUE 1-2, P161-163, November 15, 2013

Interactions of environment and genes in multiple sclerosis

Published:September 05, 2013DOI:https://doi.org/10.1016/j.jns.2013.08.018

      Abstract

      MS susceptibility is comprised of both genetic and environmental factors and it has become increasingly clear that these interact. The major histocompatiblity complex is the major site of the interactions which determine MS risk.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the Neurological Sciences
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Willer C.J.
        • Dyment D.A.
        • Sadovnick A.D.
        • Rothwell P.M.
        • Murray T.J.
        • Ebers G.C.
        • et al.
        Timing of birth and risk of multiple sclerosis: population based study.
        BMJ. Jan 15 2005; 330: 120
        • Lincoln M.R.
        • Montpetit A.
        • Cader M.Z.
        • Saarela J.
        • Dyment D.A.
        • Tiislar M.
        • et al.
        A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis.
        Nat Genet. 2005; 37: 1108-1112
        • Ramagopalan S.V.
        • Link J.
        • Byrnes J.K.
        • Dyment D.A.
        • Giovannoni G.
        • Hintzen R.Q.
        • et al.
        HLA-DRB1 and month of birth in multiple sclerosis.
        Neurology. 2009; 73: 2107-2111