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Short communication| Volume 334, ISSUE 1-2, P183-185, November 15, 2013

A new clinical variant of the post-malaria neurological syndrome

Published:September 12, 2013DOI:https://doi.org/10.1016/j.jns.2013.08.012

      Abstract

      Post-malaria neurological syndrome (PMNS) is an uncommon, monophasic illness that occurs within two months following recovery from Plasmodium falciparum (Pf) malaria. Clinical manifestations of PMNS are variable, but published cases uniformly feature neurological and/or psychiatric symptoms without long tract signs. We describe a case of severe brainstem and spinal cord inflammation with paraplegia and sphincter involvement in a 48 year old woman following recovery from a Pf malarial illness. We propose that this case represents a previously unreported form of PMNS, which has features that distinguish it from acute disseminated encephalomyelitis, and that the recognised clinical spectrum of PMNS should be extended to include brainstem and spinal cord inflammation.

      Keywords

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      References

        • Nguyen T.H.M.
        • Day N.P.J.
        • Chuong L.V.
        • Waller D.
        • Nguyen H.P.
        • Bethell D.B.
        • et al.
        Post-malaria neurological syndrome.
        Lancet. 1996; 348: 917-921
        • World Health Organisation
        • Communicable Diseases Cluster
        Severe falciparum malaria.
        Trans R Soc Trop Med Hyg. 2000; 94: S1-S90
        • Markley J.D.
        • Edmond M.B.
        Post-malaria neurological syndrome: a case report and review of the literature.
        J Travel Med. 2009; 16: 424-430
        • Kochar D.K.
        • Sirohi P.
        • Kochar S.K.
        • Bindal D.
        • Kochar A.
        • Jhajharia A.
        • et al.
        Post-malaria neurological syndrome — a case of bilateral facial palsy after Plasmodium vivax malaria.
        J Vector Borne Dis. 2007; 44: 227-229
        • Senanayake N.
        • de Silva H.J.
        Delayed cerebellar ataxia complicating falciparum malaria: a clinical study of 74 patients.
        J Neurol. 1994; 241: 456-459
        • van der Wal G.
        • Verhagen W.I.M.
        • Dofferhoff A.S.M.
        Neurological complications following Plasmodium falciparum infection.
        Neth J Med. 2005; 63: 180-183
        • Odawara T.
        • Matsumura T.
        • Maeda T.
        • Washizaki K.
        • Iwamoto A.
        • Fujii T.
        A case of post-malarial neurological syndrome (PMNS) after treatment of falciparum malaria with artesunate and mefloquine.
        Trop. Med. Health. 2009; 37: 125-128
        • Mohsen A.H.
        • McKendrick M.W.
        • Schmid M.L.
        • Green S.T.
        Post-malarial neurological syndrome: a case of acute disseminated encephalomyelitis?.
        J Neurol Neurosurg Psychiatry. 2000; 68: 388-390
        • Koibuchi T.
        • Nakamura T.
        • Miura T.
        • Endo T.
        • Nakamura H.
        • Takahashi T.
        • et al.
        Acute disseminated encephalomyelitis following Plasmodium vivax malaria.
        J Infect Chemother. 2003; 9: 254-256